SKU: 51667347083

PDIA3 Rabbit Polyclonal Antibody

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Description

PDIA3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen PDIA3 Synonyms Protein disulfide isomerase A3; 58 kDa glucose regulated protein; 58 kDa microsomal protein (p58); Disulfide isomerase ER 60; Endoplasmic reticulum resident protein 57 (ER protein 57; ERp57); Endoplasmic reticulum resident protein 60 (ER protein 60; ERp60); ERP57; ERP60; GRP58 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P30101 Antibody Type Polyclonal antibody Isotype

Product Specification


Host Rabbit
Antigen PDIA3
Synonyms Protein disulfide-isomerase A3; 58 kDa glucose-regulated protein; 58 kDa microsomal protein (p58); Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57 (ER protein 57; ERp57); Endoplasmic reticulum resident protein 60 (ER protein 60; ERp60); ERP57; ERP60; GRP58
Immunogen Synthetic Peptide
Location Endoplasmic reticulum
Accession P30101
Antibody Type Polyclonal antibody
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu
Positive Sample HepG2, Daudi, HeLa, HaCat, 293T, PC-3, human colon, human colon cancer, human endometrium cancer, human lung cancer, human thyroid cancer
Predicted Reactivity Bv, AfGrMk
Purification Immunogen Affinity
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu
ICC 1:500 Hu

Background

PDIA3 (Protein Disulfide Isomerase Family A Member 3), also known as ERp57 or GRP58, is a multifunctional enzyme belonging to the protein disulfide isomerase (PDI) family. It is predominantly located in the endoplasmic reticulum (ER) and acts as a molecular chaperone and redox catalyst. PDIA3 interacts with lectin chaperones like calreticulin and calnexin to facilitate the folding of newly synthesized glycoproteins by promoting the formation of disulfide bonds. Additionally, it prevents protein aggregation and plays a role in the unfolded protein response (UPR) during ER stress. Beyond its canonical functions, PDIA3 has been implicated in various biological processes, including viral infections, where it can influence viral entry and replication. In disease contexts, PDIA3 is often upregulated in cancers and has been associated with tumor progression and drug resistance. Recent studies also highlight its involvement in metabolic disorders, such as obesity, by regulating the function of adipose tissue macrophages.

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SKU: 51667347083

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4.8 ★★★★★
Based on 22 reviews
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Product Reviews
K
Verified Purchase
Kindle Customer Maureen
Charlottesville, US
★★★★★ 4
Slow, sorry but good
Format: Kindle
This was a slow moving book. Lots of character pov chapters, lots of superfluous descriptions and endless courtly appearances stalled this book to start. Once you get into the heart of the story, it takes off. Before you know it the book is done. My favorite character is Reyna. She is so strong. She is true to herself. She gets into a lot of trouble with her headstrong ways but it's entertaining. I have high hopes for Lorcan. He is honorable to a fault. Thane had turned out to be better than I thought but i still don't like him. Eislin is useless. Great plot twists at the end. I'm looking forward too book 2.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2020
F
Verified Purchase
Faifre6
Alexandria, US
★★★★★ 5
Very detailed! Beautiful world building! Strong Heroine!
Format: Kindle
Starts off a little slow and confusing with different POV’s, but starts to all come together towards the middle to make an elaborate plot line and makes it all worth it. Beautiful world building and attention to detail as well as great writing. The cliffhanger was gut wrenching! Can’t wait for the next book!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 4, 2020
I
Verified Purchase
Isabelle
Charlottesville, US
★★★★★ 4
Interesting
Format: Kindle
This was a very captivating book once you got into it thoroughly. But the third person perspective was a bit hard to get used to. But as you got into it and followed the different characters, it was interesting and filled with intrigue, conflict and forbidden love. I can’t wait to read the next one and to complete the series.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 12, 2022
L
Verified Purchase
Lisa B.
Lake Worth, US
★★★★★ 5
OUTSTANDING
Format: Kindle
This was very, very good. The world is vast and characters are complex. There is a good plot with a whole lot going on. This is well written. Good twists and turns and some heart breaking moments. You will love these characters, they have heart and loyalty. I am hoping that there will be several more books. We've yet to see anything from the Sea Court but only a mention of them here and there. The Wood Court was given a quick couple of scenes, and only as far as some warriors, we've yet to enter their court and the Shadow Court, I'm not sure if they will be a force for good or bad, but they definitely will play a much bigger role moving forward. This is primarily the Ice and Air Courts. Told in multiple views, which I loved, it gives you a chance to see things from different eyes. There's alot of political maneuvering and deception. I loved it and will pick up the next book as it becomes available. If you like The Fae and the courts, you should love this. I think the author has mucn in store for us.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 8, 2020
J
Verified Purchase
Jessika
Lowell, US
★★★★★ 4
Definitely worth the read!
Format: Kindle
After taking a deep breath and taking in that wicked twist of an ending, I have finally composed myself. My first thought when I started this book was that I love Reyna's character. I was intrigued by her connection with her familiar and the Ruin that is plaguing her land. It came as no surprise that she took her sister's place in an attempt to protect her. When they reach the Air Court everything slows down. This is where it was iffy for me. First of all, I like multiple POV's in books however 7 is a bit much. It starts to interrupt the story line. I felt like I was finally making progress connecting with one character, then it was switched to another person. I felt they all had necessary or pertinent information but not necessarily were they all POV worthy. The only other thing that annoyed me was that Reyna constantly was " trapped." She would rush off without thinking, only to need rescuing. She is brilliant in a fight, but she really doesn't think through anything. Lorcan is amazing. I know he might be on the "bad" list, but his background is so interesting. Eislyn(Reyna's sister) is really so sweet, but calculating. I enjoyed her and Thane's dialogue. The author did an amazing job with the imagery in this book. Everything was so detailed it was easy to fall into the scene. I love unexpected twists and while part of the ending I expected, I wasn't expecting how it took place. All in all, I found it very entertaining and I am very invested in continuing this series. Favorite quotes: "The truth may be twisted but never false." "Who was she if she was not the enemy of the Air Court? What was her purpose of she no longer has that?" "In a war-torn land, love was always a lie."
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 4, 2020

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