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Description
PKR Recombinant Rabbit mAb (S-731-118)Product Specification Host Rabbit Antigen PKR Synonyms Interferon induced, double stranded RNA activated protein kinase; Eukaryotic translation initiation factor 2 alpha kinase 2 (eIF 2A protein kinase 2); Interferon inducible RNA dependent protein kinase; P1 eIF 2A protein kinase; Protein kinase RNA activated (PKR; Protein kinase R); Tyrosine protein kinase EIF2AK2; p68 kinase; PRKR; EIF2AK2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus
Product Specification
| Host | Rabbit |
| Antigen | PKR |
| Synonyms | Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2); Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated (PKR; Protein kinase R); Tyrosine-protein kinase EIF2AK2; p68 kinase; PRKR; EIF2AK2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P19525 |
| Clone Number | S-731-118 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | MCF7, HEK-293, K562, HeLa, HepG2, Jurkat |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
PKR, also known as Protein Kinase R or double-stranded RNA-dependent protein kinase, is a serine/threonine catalytic enzyme that plays a crucial role in innate immune responses against viral infections. It is an interferon-induced kinase that can be activated by double-stranded RNA (dsRNA), a common byproduct of viral replication. Once activated, PKR phosphorylates the eukaryotic initiation factor 2α (eIF2α), which inhibits protein synthesis and viral replication. Additionally, PKR can activate the NF-κB signaling pathway, enhancing the expression of antiviral genes. Beyond its antiviral functions, PKR is involved in various cellular processes, including apoptosis, cell growth, and differentiation. Its dysregulation has been implicated in several diseases, including cancer, making it a potential therapeutic target.
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