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Description
53BP1 Recombinant Rabbit mAb (S-3170-149)Product Specification Host Rabbit Antigen 53BP1 Synonyms TP53 binding protein 1; 53BP1; p53 binding protein 1; p53BP1; TP53BP1 Immunogen Synthetic Peptide Location Nucleus Accession Q12888 Clone Number S 3170 149 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HT 29, HCT 116 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | 53BP1 |
| Synonyms | TP53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1; TP53BP1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q12888 |
| Clone Number | S-3170-149 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HT-29, HCT 116 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
53BP1 (p53-binding protein 1) is a large, multi-domain scaffold protein that rapidly accumulates in irradiation-induced foci at DNA double-strand breaks, where it acts as a master regulator of the non-homologous end-joining repair pathway by binding phosphorylated H2AX (γH2AX) and histone H4 methylated on Lys20, thereby recruiting the downstream effector kinase ATM, the ubiquitin ligases RNF8/RNF168, and the adaptor proteins BRCA1 and RIF1 to antagonize BRCA1-mediated DNA-end resection and channel repair toward the error-prone but fast NHEJ route, while its own recruitment and retention are governed by tandem Tudor and BRCT domains that sense combinatorial histone marks, and its loss or mutation leads to genomic instability, hypersensitivity to ionizing radiation, and impaired class-switch recombination in B lymphocytes.
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