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Description
Human IL-4R Recombinant Rabbit mAb (S-3928)Product Specification Host Rabbit Antigen IL 4R Clone Number S 3928 Antibody Type Recombinant mAb Isotype IgG Application ELISA Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application dilution species ELISA 1: 5000 1: 10000 Hu
Product Specification
| Host | Rabbit |
| Antigen | IL-4R |
| Clone Number | S-3928 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ELISA | 1:5000-1:10000 | Hu |
Background
Human IL-4R (Interleukin-4 Receptor) is a critical cell surface receptor involved in immune regulation and inflammatory responses, composed of the IL-4Rα chain (CD124) paired with either the common γ-chain (γc, CD132) or IL-13Rα1 to form Type I or Type II receptors. It binds cytokines IL-4 and IL-13, activating JAK-STAT signaling pathways that modulate immune cell functions, particularly in hematopoietic cells such as B cells, T cells, macrophages, and mast cells. IL-4R signaling promotes Th2 cell differentiation, IgE antibody class switching, and anti-inflammatory responses, playing a central role in allergic and immune-mediated diseases. Dysregulation of IL-4R is associated with conditions like asthma, atopic dermatitis, and autoimmune disorders. Due to its therapeutic potential, IL-4R has been successfully targeted by drugs such as dupilumab, offering effective treatment for allergic diseases. Ongoing research continues to explore IL-4R's broader roles in immunity and inflammation, paving the way for novel therapies targeting immune dysregulation.
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