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Description
Biotin Mouse Anti-Human CD200 Antibody (S-R582)Product Specification Host Mouse Antigen CD200 Synonyms OX 2 membrane glycoprotein; MOX1; MOX2 Location Cell membrane Accession P41217 Clone Number S R582 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD200 |
| Synonyms | OX-2 membrane glycoprotein; MOX1; MOX2 |
| Location | Cell membrane |
| Accession | P41217 |
| Clone Number | S-R582 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD200, also known as OX-2 membrane glycoprotein, is a type I transmembrane protein encoded by the CD200 gene and belongs to the immunoglobulin superfamily. It is primarily expressed on various cell types, including immune cells, neuronal cells, and some non-hematopoietic cells. CD200 plays a crucial role in immune regulation by interacting with its receptor, CD200R, which is mainly expressed on myeloid cells, microglia, and activated T cells. This interaction generates inhibitory signals that suppress immune responses, such as reducing the production of inflammatory cytokines like IL-2 and IFN-γ, and promoting the expansion of regulatory T cells. In addition, CD200 is involved in maintaining immune tolerance and preventing autoimmune diseases. However, its expression on tumor cells can lead to immune evasion by inhibiting antitumor T-cell responses. Therefore, CD200 is considered a potential target for cancer immunotherapy and the treatment of inflammatory and autoimmune diseases.
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