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Description
IL-12 R beta 1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IL 12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL 12RB1 Accession P42701 Amino Acid Sequence Cys24 Glu540, with C hIgG Fc Expression System CHO Molecular Weight 95 110kDa (Reducing) Purity 95% by SDS PAGE & >95% by SEC HPLC Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1 |
| Accession | P42701 |
| Amino Acid Sequence | Cys24-Glu540, with C-hIgG Fc |
| Expression System | CHO |
| Molecular Weight | 95-110kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Pérez-Martínez L, Romero L, Verdugo-Sivianes EM, Muñoz-Galván S, Rubio-Mediavilla S, Amiama-Roig A, Carnero A, Blanco JR. Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome. PLoS One. 2024 Jan 10;19(1): e0286201. l. (2008) Nat. |
Background
IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
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