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Description
RANTES/CCL5 Protein, HumanProduct Specification Species Human Synonyms CCL 5, D17S136E, RANTES, SCYA5, SIS delta, SISd, TCP228, eoCP, C C motif chemokine ligand 5 Accession P13501 Amino Acid Sequence Ser24 Ser91 Expression System E. coli Molecular Weight Approximately 7. 8 kDa, a single non glycosylated polypeptide chain containing 68 amino acids. Purity 97% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH
Product Specification
| Species | Human |
| Synonyms | CCL-5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5 |
| Accession | P13501 |
| Amino Acid Sequence | Ser24-Ser91 |
| Expression System | E.coli |
| Molecular Weight | Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 68 amino acids. |
| Purity | ＞97% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
Chemokine (C-C motif) ligand 5 (CCL5) also known as RANTES is classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites which has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells. It also induces the proliferation and activation of certain natural-killer cells to form CHAK cells. Recombinant human CCL5 shares 84 % a.a. sequence identity with murine and rat CCL5, respectively. Recombinant Human RANTES (CCL5) is a 7.8kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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