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Description
Phospho-Stat3 (Tyr705) Recombinant Rabbit mAb (S-1829-143)Product Specification Host Rabbit Antigen Phospho Stat3 (Tyr705) Synonyms Signal transducer and activator of transcription 3; Acute phase response factor; APRF; STAT3 Immunogen Synthetic Peptide Location Nucleus Accession P40763 Clone Number S 1829 143 Antibody Type Recombinant mAb Isotype IgG Application WB, IP Reactivity Hu, Ms, Rt Predicted Reactivity Bv, Pg Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Stat3 (Tyr705) |
| Synonyms | Signal transducer and activator of transcription 3; Acute-phase response factor; APRF; STAT3 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P40763 |
| Clone Number | S-1829-143 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Pg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
| IP | 1:50 | Hu |
Background
Phospho-Stat3 (Tyr705) is a critical biomarker indicating the activation of the STAT3 protein, a latent cytoplasmic transcription factor involved in various cellular processes such as proliferation, survival, and immune response. When phosphorylated at tyrosine 705, STAT3 undergoes dimerization and translocates to the nucleus, where it binds to DNA and regulates gene expression. This phosphorylation is primarily mediated by the JAK family of receptor-associated tyrosine kinases, particularly JAK1, in response to cytokine signaling. Phospho-Stat3 (Tyr705) is also implicated in diseases like cancer, where its constitutive activation is observed in various tumor types.
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