SKU: 47219130516

CD117/c-Kit Fc Chimera Protein, Mouse

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Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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SKU: 47219130516

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D. E. Washington
Chelsea, US
★★★★★ 5
Nice shirt
Color: Blue/White, Size: X-Large
Nice shirt
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Reviewed in the United States on April 16, 2026
D
Verified Purchase
Do NOT have shipped without the extra box
Chelsea, US
★★★★★ 5
Good for the price point
Color: Olive 09, Size: Medium
I bought this as a Christmas gift for one of my teen boys. I originally bought this shirt for our 16 year old but when I received it, I quickly realized the quality would be off putting to him, so I gifted it to one of my other boys that is not a material/brand snob. The color is spot on with the description. Our son loves the shirt’s thin knit and softness when wearing. The quality could be better but it’s good for the price point. Fits as described and is holding up to our fifteen year old nicely. Would buy again.
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Reviewed in the United States on February 17, 2026
F
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flredsox
West Palm Beach, US
★★★★★ 5
Perfect Fit, Perfect Material
Color: Lt Blue 09, Size: Large
Large was a perfect fit for me. Chest, shoulders and waste perfect. Arms surprisingly long as I have long arms (35”). I had to pull up the left sleeve to get out of my grip. Material was very soft, light and stretchy. Perfect to keep arms out of the sun and still cool enough on a 94 degree here in Florida. For those w a belly, this might not work. I have a flat stomach some love handles and somewhat squarish body type (not a V..I’m 71) so perfect belly space for me. I’m 6’, 185. The other issue for me is my shoulder arthritis and getting a sweaty shirt off, no problem. The shirt wicked away the water and the shirt was stretchy enough to get it off easily. I am going to wash it and make sure it holds it shape then if positive I will buy a couple more. I’ve tried several shirts, this is great!
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Reviewed in the United States on May 24, 2026
A
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Amazon Customer
Pawtucket, US
★★★★★ 4
Nice Bus casual Fit
Color: Black 09, Size: X-Large
I love the feel of the shirt. I got an XL and it's a little big. I'm 6' 2" about 230 I'm gonna order a large to compare. Over I like the shirt.
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Reviewed in the United States on January 24, 2026
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Juan R.
San Leandro, US
★★★★★ 5
Gran precio y calidad
Color: Black 09, Size: Medium
Muy buen diseño en el cuello interno y muy buena calidad.
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Reviewed in the United States on May 12, 2026

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