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Description
ATG7 Recombinant Rabbit mAb (S-1279-201)Product Specification Host Rabbit Antigen ATG7 Synonyms Ubiquitin like modifier activating enzyme ATG7; ATG12 activating enzyme E1 ATG7; Autophagy related protein 7 (APG7 like; hAGP7); Ubiquitin activating enzyme E1 like protein; APG7L Immunogen Synthetic Peptide Location Cytoplasm Accession O95352 Clone Number S 1279 201 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms Positive Sample HeLa, Jurkat, HEK 293, HT
Product Specification
| Host | Rabbit |
| Antigen | ATG7 |
| Synonyms | Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7 (APG7-like; hAGP7); Ubiquitin-activating enzyme E1-like protein; APG7L |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O95352 |
| Clone Number | S-1279-201 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, Jurkat, HEK-293, HT-29, human endometrial cancer, human pancreas, human testis, human tonsil |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
Background
ATG7 is an essential autophagy effector enzyme that plays a crucial role in the autophagy process, which is vital for cellular degradation and recycling. Structurally, ATG7 is a symmetric homodimer with two catalytic cysteine residues. It functions as an E1-like enzyme, activating two major ubiquitin-like proteins involved in autophagy: ATG12 and LC3. These proteins are then conjugated to other autophagy-related molecules, such as ATG5 and phosphatidylethanolamine, to facilitate the formation of autophagosomes. Beyond its role in autophagy, ATG7 is also involved in regulating immunity, cell death, protein secretion, and even cell cycle progression in response to metabolic stress.
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