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Description
Vinculin Recombinant Mouse mAb (S-916-217)Product Specification Host Mouse Antigen Vinculin Synonyms Metavinculin (MV); VCL Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane Accession P18206 Clone Number S 916 217 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, A431, HepG2, K562, NIH 3T3, C6, rat heart Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | Vinculin |
| Synonyms | Metavinculin (MV); VCL |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane |
| Accession | P18206 |
| Clone Number | S-916-217 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, A431, HepG2, K562, NIH/3T3, C6, rat heart |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
Vinculin is a highly conserved, ubiquitously expressed cytoskeletal adaptor protein that localizes to both cell-cell and cell-matrix adhesion sites, where it functions as a central regulator of mechanotransduction by coupling integrins to the actomyosin cytoskeleton through its head-domain binding to talin and its tail-domain binding to F-actin, PIP2 lipids, and multiple actin-organizing proteins, thereby stabilizing focal adhesions and adherens junctions in response to tension and phosphoinositide signals that trigger its transition from an auto-inhibited closed state to an active open conformation.
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