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Description
Human folate receptor alpha Recombinant Rabbit mAb (SDT-719-684)Product Specification Host Rabbit Antigen Human folate receptor alpha Synonyms Folate receptor alpha; FR alpha; Adult folate binding protein (FBP); Folate receptor 1; Folate receptor; adult; KB cells FBP; Ovarian tumor associated antigen MOv18; FOLR; FOLR1 Immunogen Synthetic Peptide Location Secreted, Endosome, Cell membrane Accession P15328 Clone Number SDT 719 684 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu
Product Specification
| Host | Rabbit |
| Antigen | Human folate receptor alpha |
| Synonyms | Folate receptor alpha; FR-alpha; Adult folate-binding protein (FBP); Folate receptor 1; Folate receptor; adult; KB cells FBP; Ovarian tumor-associated antigen MOv18; FOLR; FOLR1 |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Endosome, Cell membrane |
| Accession | P15328 |
| Clone Number | SDT-719-684 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:100-1:250 | Hu |
Background
Human folate receptor alpha (FOLR1) is a glycoprotein that plays a crucial role in the transport of folate, an essential vitamin, into cells. This receptor is highly expressed in certain tissues and is particularly notable for its involvement in various physiological processes including embryonic development and cellular proliferation. Its overexpression has been observed in numerous cancers, such as ovarian, lung, and breast cancer, making it a potential target for cancer diagnosis and targeted therapy. By binding to folate or folate analogs, FOLR1 facilitates the internalization of these molecules via endocytosis, thereby providing cells with the necessary folate for metabolic functions like DNA synthesis and repair.
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