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Description
Alexa Fluor® 488 Mouse Anti-Human CD146 Antibody (S-3679)Product Specification Host Mouse Antigen CD146 Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; S endo 1 endothelial associated antigen; MUC18; MCAM Location Membrane Accession P43121 Clone Number S 3679 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G
Product Specification
| Host | Mouse |
| Antigen | CD146 |
| Synonyms | Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; MUC18; MCAM |
| Location | Membrane |
| Accession | P43121 |
| Clone Number | S-3679 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD146, also known as melanoma cell adhesion molecule (MCAM), is a 113-kDa, heavily glycosylated type-I transmembrane glycoprotein of the immunoglobulin superfamily that consists of five Ig-like domains (V-V-C2-C2-C2), a single transmembrane segment and a cytoplasmic tail existing in a long and a short splice isoform; initially identified on melanoma cells, it now is recognized as a multifunctional adhesion and signaling receptor widely expressed on endothelial cells, pericytes, smooth muscle, activated T cells and various stem cells that, through homophilic interactions and ligands such as laminin-411, Wnt5a and galectin-1, orchestrates angiogenesis, vascular integrity, cell migration, immune-cell trafficking and epithelial–mesenchymal transition, while its overexpression and elevated glycosylation in melanoma, renal, prostate, lung, pancreatic and other cancers correlate with tumor progression, metastasis and poor prognosis, and its soluble ectodomain (sCD146) released by metalloprotease shedding functions as a circulating biomarker, making CD146 a valuable diagnostic and therapeutic target in oncology and inflammatory diseases.
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