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Description
APC Mouse Anti-Human CD14 Antibody (S-631-50)Product Specification Host Mouse Antigen CD14 Synonyms Monocyte differentiation antigen CD14; My23 antigen; Myeloid cell specific leucine rich glycoprotein Immunogen Recombinant Protein Location Secreted, Cell membrane Accession P08571 Clone Number S 631 50 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 05mg ml Conjugation APC Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | CD14 |
| Synonyms | Monocyte differentiation antigen CD14; My23 antigen; Myeloid cell-specific leucine-rich glycoprotein |
| Immunogen | Recombinant Protein |
| Location | Secreted, Cell membrane |
| Accession | P08571 |
| Clone Number | S-631-50 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein primarily expressed on monocytes, macrophages, and some granulocytes. It functions as a pattern recognition receptor (PRR) and plays a crucial role in the innate immune response by recognizing bacterial lipopolysaccharides (LPS), pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). CD14 exists in two forms: membrane-bound CD14 (mCD14) and soluble CD14 (sCD14), which can be secreted by activated cells. It acts as a co-receptor for Toll-like receptor 4 (TLR4) and enhances the immune response to LPS by facilitating its delivery to the TLR4-MD2 complex. Additionally, CD14 is involved in TLR4-independent signaling pathways and contributes to tissue homeostasis by promoting the clearance of apoptotic cells.
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4.2 ★★★★★
Based on 21 reviews
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Product Reviews
★★★★★ 5
Awesome enrichment toy!
Size: Large, Color: Green, Size: Large, Color: Green
These are awesome! My dogs love them and keep them occupied for 30-60 mins so I can make and enjoy my coffee in peace before work. They are very easy to clean, but as others have mentioned, they can get stuck. I had to take a pliers to get one of them unscrewed. Hopefully that’s not a constant issue. I do wish they were more durable since there were a lot of teeth marks in them after the first use, so I upgraded to the black super chewer one. I’m happy I gave these a try and feel they are worth the money, especially for high energy dogs who get bored easily.
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Reviewed in the United States on June 4, 2026
★★★★★ 5
Best toy/treat! (Use oil on inner screw to open)
Size: Large, Color: Green
My dogs love these! This gives them a dedicated 20-40min of dog joy. They often get up halfway thru and switch but whatever makes them happy. They do get STUCK! And can be impossible to open. I now use a dot of olive oil on each level of the screw and then twist it in and out a couple times to distribute the lube so its possible to open when they are done. I find it very important to collect them immediately when they are done and open back up for cleaning. Do not let them dry as it will be very difficult to open.
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Reviewed in the United States on June 11, 2026
★★★★★ 5
These are must haves for dog owners!
Size: Large, Color: Pink
These things have saved my sanity! I have two dogs and we use these at least two to three times per week. They are high quality and last thru heavy chewers. We spread peanut butter inside for a quick treat when clipping nails, or make our own mix of Greek yogurt, dry oatmeal, diced carrots, a little pumpkin, and a bit of diced apple, mix it up and freeze it in the Pupsicle mold. That way we have a bunch ready to go and aren’t buying expensive refills. The colors are adorable, the pupsicle is durable, and the dogs LOVE them. FYI - it’s a good idea to use a little olive or avalado oil on the threads when closing them up - it makes life so much easier when screwing then on and off. We throw ours into the dishwasher.
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Reviewed in the United States on June 6, 2026
★★★★★ 5
Like unto the Holy Grail of food toys. [I recommend buying the separate treat mold, too.]
Size: Large, Color: Green
So far, I have no complaints. I can see that this toy might not work well for some combinations of dogs and people, but for my two current dogs (blue heeler and small terrier), this thing, plus the treat mold, is GREAT!
I love that the dogs get it more or less fully emptied, and it is washable. I love that I can pre-prepare a whole bunch of frozen fillings by using the treat mold (sold separately).
Yes, I agree that this is a very expensive item, especially if you buy the treat mold along with the toy. I bought two toys at a very reduced price on Prime day, also bought the treat mold at full price, and consider the combined purchase a great value at this cost. The current price (for the toy) is comparable to the cost of an extra-large Toppl, and I've seen it at a price similar to the current cost of a large Toppl. I checked the current price of the XXL "extreme" Kong I needed to use for one dog, and the current price on a different web site is almost the same as the Woof Pupsicle.
To answer questions and issues I've seen mentioned...
* My terrier weighs 16 pounds and uses the large toy with no problem. Possibly it is minimally less thoroughly cleaned out, but I'm not positive about that. My only warning would be that you ought to keep track of calories and/or what you put in it because you could potentially give a small dog way too many empty calories from "junk food."
* The toy is still usable without the treat mold. Just fill up the solid half of the toy and stick it in the freezer overnight, same as you would do with a Kong, except it takes up less space.
* Do introduce it properly, by initially giving it with NON-frozen and sticky food in it. An even more slow, careful, step-wise introduction may be necessary if your dog is a destructo-dog.
* The terrier takes about 20 minutes to empty it of frozen canned dog food. That's non-trivial, and I'm not sure why people are complaining. The heeler takes less time (maybe 15 minutes?), but it's still an amount of time that is helpful for me, and this licking activity seems to be especially calming for her (as compared to using the food puzzle toys with kibble).
* It initially was extremely difficult to open and close the thing. I was best able to do it with a "light" touch, not pulling and making sure not to press the two surfaces together. After not very long, it became much easier. I didn't need to use oil. If you have trouble getting it closed, it became a lot easier after the solid part was frozen (while the vented part stayed at room temperature).
* I agree with others that a larger version might be nice, but a larger version might make dogs more likely to destroy the toy in place of emptying it by focused licking.
* I'm not sure that any of these toys are truly indestructible. People are mentioning Kongs. Well, my Kongs have required periodic replacement. They have tooth marks and eventually get "modified" to where pieces might get torn off and consumed. For one dog, I had to upgrade to the XXL-size Extreme (black) version, and she also put tooth marks in that.
I own a fortune's worth of Kongs, Toppls, and a couple similar food toys, and they all have their issues. They have holes in them that allow liquid to immediately come out (before freezing occurs). They are bulky and use up a lot of space in the freezer, and the unusual shapes make them non-stackable. For me, Kong toys are time-consuming to fill and difficult to clean. My dogs couldn't get the very end cleaned out without throwing the Kong around (making a big mess), and even then it wasn't fully clean. Some did end up with mold in that part of them. [It looks like new inventions, like plugs (or something like that), may solve some of the problems; I didn't have those.]
I mention the other toys only to say that this unique brilliant toy has seeming solved all those problems, and my dogs truly LOVE this toy as well. Be assured, I will update this review if anything changes.
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Reviewed in the United States on July 24, 2023
★★★★★ 4
Perfect for Our Nervous Rescue Dog
Size: Large, Color: Green
First Impressions
I bought the Pupsicle for our new rescue dog who was very nervous whenever we had to leave the house. Right out of the box it felt sturdy and well-made, and I liked that it wasn’t just another cheap chew toy.
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Setup & Ease of Use
I went with the premade treat inserts to start, which made it super simple — just pop one in and hand it over. It’s also dishwasher-safe, which is a huge win for me since I don’t want to deal with scrubbing peanut butter out of toys.
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Performance in Real Life
She loves it. The Pupsicle has kept her occupied and calm, which has really helped her acclimate to her new home. Instead of pacing or whining when we leave, she settles down with this toy and stays busy.
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Pros & Cons
Pros:
• Helps reduce anxiety for nervous dogs
• Very durable and solid
• Easy to clean (dishwasher safe)
• Premade inserts make it effortless
Cons:
• On the heavier side, so probably best for medium+ dogs
• Inserts are convenient but add a little extra cost
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Who It’s For
Perfect for new dog owners, rescues, or anyone with a dog who needs a healthy distraction when left alone.
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Final Verdict
The Pupsicle has made a noticeable difference for our rescue pup. It’s durable, easy to use, and has genuinely helped her feel more at ease in her new environment. Highly recommend.
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Reviewed in the United States on August 24, 2025