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Description
LIN28A Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen LIN28A Synonyms Protein lin 28 homolog A; Lin 28A; Zinc finger CCHC domain containing protein 1; CSDD1; LIN28; ZCCHC1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Endoplasmic reticulum Accession Q9H9Z2 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms Positive Sample T 47D, NCCIT, JAR, NTERA 2, F9 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | LIN28A |
| Synonyms | Protein lin-28 homolog A; Lin-28A; Zinc finger CCHC domain-containing protein 1; CSDD1; LIN28; ZCCHC1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Endoplasmic reticulum |
| Accession | Q9H9Z2 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | T-47D, NCCIT, JAR, NTERA-2, F9 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
| IHC-P | 1:500-1:1000 | Hu, Ms |
Background
LIN28A is an evolutionarily-conserved RNA-binding protein that harbors a cold-shock domain and two CCHC-type zinc knuckles, enabling it to dock onto specific motifs (e.g., UGAU loops) in mRNAs and micro-RNA precursors; by blocking the biogenesis of the tumor-suppressive let-7 family and by directly stabilizing or enhancing translation of metabolic, hypoxic and pluripotency transcripts (including HIF1α, IGF2BP3 and OCT4 targets), LIN28A sustains pluripotency, drives aerobic glycolysis, fosters embryonic and adult tissue regeneration, and when re-activated in cancers promotes stemness, angiogenesis, epithelial-to-mesenchymal transition, chemoresistance and poor patient prognosis.
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