SKU: 45190991407

Spike S2(GCN4-IZ) His Tag Protein, SARS-CoV-2(K986P&V987P)

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Description

Spike S2(GCN4-IZ) His Tag Protein, SARS-CoV-2(K986P&V987P)Product Specification Species Human Synonyms Spike, S2 protein Accession P0DTC2 Amino Acid Sequence Ser686 Lys1211(K986P&V987P)

Product Specification


Species Human
Synonyms Spike, S2 protein
Accession P0DTC2
Amino Acid Sequence

Ser686-Lys1211(K986P&V987P) SVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKGGGSGGGSGGGSRMKQIEDKIEEILSKIYHIENEIARIKKLVGERGGGSHHHHHH

Expression System HEK293
Molecular Weight 90-95kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Yuejun Shi, Jiale Shi, Limeng Sun, Yubei Tan, Gang Wang, Fenglin Guo, Guangli Hu, Yanan Fu, Zhen F Fu, Shaobo Xiao.Insight into vaccine development for Alpha-coronaviruses based on structural and immunological analyses of spike proteins. J Virol. 2021 Mar 10;95(7):e02284-20.Epub 2021 Jan 7.

Background

Coronaviruses that infect humans belong to the Alpha-coronavirus (including HCoV-229E) and Beta-coronavirus (including SARS-CoV and SARS-CoV-2) genera. In particular, SARS-CoV-2 is currently a major threat to public health worldwide. The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RBD), which is a major target to block viral entry. our results reveal different vaccine strategies for coronaviruses, and S-trimer is better than RBD as a target for vaccine development in Alpha-coronavirus Our findings will provide important implications for future development of coronavirus vaccines. Outbreak of coronaviruses, especially SARS-CoV-2, poses a serious threat to global public health. Development of vaccines to prevent the coronaviruses that can infect humans has always been a top priority. Coronavirus spike (S) protein is considered as a major target for vaccine development. Currently, structural studies have shown that Alpha-coronavirus (HCoV-229E) and Beta-coronavirus (SARS-CoV and SARS-CoV-2) RBDs are in "lying" and "standing" states in the prefusion S-trimer structure. Here, we evaluated the ability of S-trimer and RBD to induce neutralizing antibodies among these coronaviruses. Our results showed that the S-trimer and RBD are both candidates for subunit vaccines in Beta-coronavirus (SARS-CoV and SARS-CoV-2) with a RBD "standing" state. However, for Alpha-coronavirus (HCoV-229E) with a RBD "lying" state, the S-trimer may be more suitable for subunit vaccines than the RBD. Our results will provide novel ideas for the development of vaccines targeting S protein in the future.

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SKU: 45190991407

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4.6 ★★★★★
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María Ángeles Hidalgo de Cantillo
Phoenix, US
★★★★★ 5
Highly recommended product.
Style: Purple-30oz
A great machine—it is very useful to me and helps new ventures a lot.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026
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Ron Busbee
Bozeman, US
★★★★★ 1
Barely qualifies as a product
Style: 12x10
This thing is a FAIL on so many levels that I can't even begin to describe how bad it is. I bought the 12 x 15 press because I thought it would be fun to have a smaller press at the house that I could use to knock out things like mouse pads and coasters when I didn't feel like going to my studio and using my other machines. What a mistake. Uneven heat is just one of the issues. The biggest problem is that when you pull the arm down instead of the springs, adjusting to any height that might come from a coaster or a mouse pad, the whole heat plate just gets pushed back in the pylon, while at the same time, the platform holding the unattached rubber plate tilts down at the front, causing it to sit crooked and not work. It overheats the pieces in the back and under heats the pieces in the front because of the gap it creates.. It's awful . The timer didn't work . The temperature begins to go down as soon as you start applying the heat plate. It ruined everything it touched . Lesson learned - I've been in this business for a long time and I should've known better but I thought for the light duty minimal requirements that I wanted this would probably be OK but it's dismal . It's beyond dismal - buyer beware - don't say I didn't warn you.
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Reviewed in the United States on May 24, 2025
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David Dimas
Lexington, US
★★★★★ 4
Great machine but...
Style: 5in1-15x15-Blue
Great machine for the price. Served it's purpose well but after about 4 months of moderate use, the control box malfunctioned. OK, cool. Let's replace the control box. Easy, right? Wrong. You won't find a replacement here on Amazon. Maybe not anywhere on the internet. Luckily the warranty has me taken care of. Purchase with caution and know that this control box has a 5 pin input that you're not gonna be able to replace if it breaks or malfunctions.
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Reviewed in the United States on May 14, 2026
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Crystal Umphrey
Natrona Heights, US
★★★★★ 5
Great
Style: 12x10
Works very well good! Compared to all others I have used this is the best size and strongest I have used! Holds very well compared to off brands from retail stores! Connects very easy! Didn’t struggle with anything!!
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Reviewed in the United States on April 24, 2026
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Dangeroustoys
Dallas, US
★★★★★ 5
Excellent press at a great value.
Style: 12x10
Press works very well. Heats up quickly and timer is a great feature. Have had no issue pressing vinyl transfers and embroidered patches. Great quality for the price. Much better than using a clothing iron.
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Reviewed in the United States on February 19, 2026

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