Pay in installments of $70.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 1 - Sep 6
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
RNF43 mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms RNF43, RING finger protein 43 Accession Q5NCP0 Amino Acid Sequence Ala34 Tyr197, with C terminal mIgG2a Fc Expression System HEK293 Molecular Weight 55 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Mouse Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | RNF43, RING finger protein 43 |
| Accession | Q5NCP0 |
| Amino Acid Sequence | Ala34-Tyr197, with C-terminal mIgG2a Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Radaszkiewicz T. et al. (2021) RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion. eLife Sciences. 10. |
Background
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A- induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and VANGL2. RNF43 triggers VANGL2 ubiquitination and proteasomal degradation and clathrin- dependent internalization of ROR1 receptor and inhibits ROR2 activation. These activities of RNF43 are physiologically relevant and block pro-metastatic WNT5A signaling in melanoma. RNF43 inhibits responses to WNT5A, which results in the suppression of invasive properties of melanoma cells.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.0 ★★★★★
Based on 24 reviews
Sort
Product Reviews
★★★★★ 5
Durability
Color: Pink
My dog absolutely loves playing with this toy!! It is made of very thick plastic and I’m thinking she won’t be able to destroy this toy very easily!! She loves for you to throw it and play tug of war with. I’m very pleased with my purchase. She is a medium size dog and it works great for her.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 30, 2025
★★★★★ 1
Not durable
Color: Pink, Color: Pink
My dog tore this toy up within hours. She’s not an aggressive chewer but took the top right off!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 29, 2026
★★★★★ 5
Tough and fun toy
Color: Blue
This toy has outlived and exceeded expectations! Our dog loves it! He normally destroys any toy within a week or two. This is our second one but the first lasted eight months.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 20, 2026
★★★★★ 1
Not for heavy chewers!
Color: Blue, Color: Blue
Didn’t last more than 10 minutes
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2026
★★★★★ 5
Built for rough use
Color: Pink
Our dog plays with it for hours
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 17, 2026
recommand products
Sapphire Red Silk Heavy Embroidered Bridal Lehenga Choli
310.23
Art Silk Embroidered Saree In Green Color
87.36
Off White Muslin Silk Printed Readymade Designer Co Ord Set
76.44
Purple Georgette Embroidered Palazzo Suit
109.20
Function Wear Viscose Jacquard Embroidered Border Work Saree In Sea Green Color
175.56