SKU: 43596975554

IFN-alpha/beta R1 His Tag Protein, Human

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Description

IFN-alpha/beta R1 His Tag Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFNAR,CRF2 1,IFN R 1,IFNAR 1,IFNBR Accession P17181 1 Amino Acid Sequence Lys28 Lys436 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 70 95kDa (Reducing) Purity 95% by SDS PAGE & > 95% by SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the

Product Specification


Species Human
Synonyms IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1,IFNBR
Accession P17181-1
Amino Acid Sequence

Lys28-Lys436 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight 70-95kDa (Reducing)
Purity >95% by SDS-PAGE & > 95% by SEC-HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Groen K, Kuratli R, Enkelmann J, Fernbach S, Wendel-Garcia PD, Staiger WI, Lejeune M, Sauras-Colón E, Roche-Campo F, Filippidis P, Rauch A; Swiss HIV Cohort Study; Trkola A, Günthard HF, Kouyos RD, Brugger SD, Hale BG. Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. J Exp Med. 2025 Jun 2;222(6):e20242039.
2.Amendolara R, D'Onofrio L, Sessa RL, Di Giulio S, Mignogna C, Coraggio L, Schirano R, Zampetti S, Malandrucco I, Pozzilli P, Giannini G, Maddaloni E, Buzzetti R. IFN-α Neutralizing Antibodies Distinguish LADA From Early-onset Type 1 Diabetes. J Clin Endocrinol Metab.
3.Abramovich C,et al.(1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

Background

Interferon α/β receptor 1 (IFNAR1) is a key component of the type I interferon (IFN-α/β) receptor. It belongs to the type II cytokine receptor family and is a type I transmembrane protein. Its extracellular region contains four fibronectin type III domains. IFNAR1 must form a functional receptor complex with another subunit, IFNAR2, to mediate type I interferon signal transduction. Upon ligand binding, the receptor activates downstream JAK kinases (such as Tyk2), which in turn phosphorylate transcription factors such as STAT1 and STAT2, initiating the expression of antiviral and immunomodulatory genes. Research suggests that its signaling mechanisms are complex: on the one hand, under specific conditions (such as during IFN-β signaling), IFNAR1 can function independently without relying on IFNAR2, and this pathway may not involve the classical JAK-STAT pathway; on the other hand, Tyk2 can stabilize IFNAR1 expression by inhibiting its endocytosis, while mutations at key tyrosine sites (e.g., Tyr466) can block STAT phosphorylation in a dominant-negative manner, confirming the central role of IFNAR1 in linking JAK and STAT. IFNAR1 itself also possesses direct antiviral activity.As the gateway for type I interferon signaling, IFNAR1 is a critical target in antiviral immunity, autoimmune diseases, and tumor immunotherapy. Hyperactivation or abnormal signaling of the receptor is associated with autoimmune diseases (such as systemic lupus erythematosus), while functional defects may increase susceptibility to viral infections. Modulation of this receptor and its signaling pathway provides important directions for the development of antiviral drugs, therapies for autoimmune diseases, and novel immune adjuvants.

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SKU: 43596975554

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MR. H.
Alexandria, US
★★★★★ 5
Super comfortable!
Size: 9, Color: Navy Blazer/Ivor
Some of the most comfortable shoes that I've ever worn/walked in! Super light on my feet. Nice casual looking and comfortable shoe for a reasonable price. I already brought 3 pair.
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Reviewed in the United States on April 21, 2026
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deloris s.
Draper, US
★★★★★ 5
Comfortable Shoes
Size: 12, Color: Navy Blazer/Ivor
This is the second time I purchased this style of shoes. They are extremely comfortable. They can be worn on casual and business events.
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Reviewed in the United States on May 25, 2026
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LindyB
Natrona Heights, US
★★★★★ 5
Great dressy sneaker to wear with business casual or jeans
Size: 11, Color: British Tan/Ivry
I got these for my husband to wear with jeans or business casual dress pants. They look sharp and professional and dress up jeans if you're going out. He says they fit comfortably and he can walk on them all day without his feet hurting. They are beautiful genuine leather so they don't get stinky. I got my husband's normal size and they fit to size.
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Reviewed in the United States on February 11, 2026
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timothy scalabrelli
Port Orchard, US
★★★★★ 4
Comfortable
Size: 9, Color: Black/Ivory
Most comfortable and roomy shoes I ever wore. Great for insoles. Looks nice too. The base of the shoe is a bit too thick but it’s fine.
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Reviewed in the United States on September 5, 2025
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tom chang
Dallas, US
★★★★★ 5
Good comfort, quality and classy
Size: 8.5, Color: Black/Ivory
’ve been wearing Cole Haan dress sneakers for work and travel, and they strike a really good balance between professional and comfortable. The biggest advantage is how lightweight they feel compared to traditional dress shoes. Most styles have sneaker-like cushioning, so you can walk or stand all day without your feet getting destroyed. The design is also versatile and look polished enough for business casual outfits but still casual enough to wear with jeans. They work especially well in office environments where a full formal shoe feels too stiff or outdated.
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Reviewed in the United States on May 10, 2026

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