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Description
EZH2 Recombinant Rabbit mAb(SDT-053-49)Product Specification Host Rabbit Antigen EZH2 Synonyms ENX 1, Enhancer of zeste homolog 2, Lysine N methyltransferase 6 Immunogen Synthetic Peptide Location Nucleus, Intracellular Accession Q15910 Clone Number SDT 053 49 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Mq Purification Protein A Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | EZH2 |
| Synonyms | ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Intracellular |
| Accession | Q15910 |
| Clone Number | SDT-053-49 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Mq |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICC | 1:500 | |
| WB | 1:5000 | |
| ICFCM | 1:500 | |
| IHC-P | 1:500 | |
| IP | 1:50 |
Background
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function. Remodeling of chromosomal heterochromatin by EZH2 is also required during cell mitosis.
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