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Description
ALPG Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen ALPG Synonyms Alkaline phosphatase, germ cell type; ALP 1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase; placental like; Germ cell alkaline phosphatase (GCAP); Placental alkaline phosphatase like (PLAP like); ALPPL; ALPPL2 Immunogen Recombinant Protein Location Cell membrane Accession P10696 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A431, PANC
Product Specification
| Host | Rabbit |
| Antigen | ALPG |
| Synonyms | Alkaline phosphatase, germ cell type; ALP-1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase; placental-like; Germ cell alkaline phosphatase (GCAP); Placental alkaline phosphatase-like (PLAP-like); ALPPL; ALPPL2 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P10696 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A431, PANC-1 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
ALPG, also known as ALPPL2 or germ-cell alkaline phosphatase, is a 532-amino-acid, GPI-anchored glycoprotein enzyme (EC 3.1.3.1) belonging to the alkaline phosphatase family that is normally restricted to testis, thymus and trophoblast but becomes aberrantly over-expressed on the surface of a broad spectrum of solid tumours—including seminoma, mesothelioma, ovarian, pancreatic and gastric cancers—where it catalyzes the hydrolysis of phosphate monoesters, contributes to tumour growth and invasion, and serves as both a cancer-specific therapeutic target and a cell-surface marker for naïve pluripotency in stem-cell biology.
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