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Description
SP1 Recombinant Rabbit mAb (S-4102)Product Specification Host Rabbit Antigen SP1 Synonyms Transcription factor Sp1; TSFP1 Location Cytoplasm, Nucleus Accession P08047 Clone Number S 4102 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ChIP Reactivity Hu, Mk Positive Sample HeLa, 293T, Ramos, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | SP1 |
| Synonyms | Transcription factor Sp1; TSFP1 |
| Location | Cytoplasm, Nucleus |
| Accession | P08047 |
| Clone Number | S-4102 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ChIP |
| Reactivity | Hu, Mk |
| Positive Sample | HeLa, 293T, Ramos, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Mk |
| IHC-P | 1:2000 | Hu |
| ICC | 1:500 | Hu |
| ChIP | 1:20-1:50 | Hu |
Background
SP1 (specificity protein 1) is a ubiquitous, C2H2-type zinc-finger transcription factor that binds GC-rich motifs (GGGCGG and related sequences) in the promoters and enhancers of thousands of human genes via its three C-terminal zinc fingers, recruiting TFIID, TFIIB, histone acetyl-transferases (p300/CBP, PCAF) and chromatin-remodeling complexes to activate or fine-tune basal and signal-dependent transcription of housekeeping, metabolic, cell-cycle, angiogenic and differentiation genes; it is tightly regulated through phosphorylation by multiple kinases (ERK, AKT, DNA-PK, CDK), acetylation, SUMOylation, prolyl-isomerization and redox status of its two critical cysteines, and its activity is modulated by oncogenic, nutrient and stress signaling, making SP1 a central hub in cancer, diabetes, cardiovascular and neurodegenerative diseases, with elevated expression often correlating with poor prognosis, while synthetic mithramycin, chromomycin and novel zinc-finger inhibitors are explored to target its DNA-binding or protein–protein interfaces therapeutically.
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