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Description
ROR1 His Tag Protein, MouseProduct Specification Species Mouse Synonyms NTRKR1, ROR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor Related 1 Accession Q9Z139 Amino Acid Sequence Gln30 Glu403, with C terminal His Expression System HEK293 Molecular Weight 60 72kDa (Reducing) Purity >95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5%
Product Specification
| Species | Mouse |
| Synonyms | NTRKR1, ROR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1 |
| Accession | Q9Z139 |
| Amino Acid Sequence | Gln30-Glu403, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa (Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588. |
Background
The Receptor Tyrosine Kinase Orphan Receptor 1 (ROR1) serves as a receptor for WNT5A and associated Wnt proteins, which are crucial in embryonic development. They regulate key cellular processes such as migration, polarity, neural patterning, and organ formation. ROR1 facilitates these functions by transmitting signals from the Wnt family of secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways.
In adult human cells, especially in cancer cells, the WNT5A/ROR1 signaling axis has been shown to activate multiple pathways beyond the two mentioned, including PI3K/AKT, MAPK, NF-κB, STAT3, and the Hippo pathway. Abnormal expression of ROR1 is observed in cancer, where it is linked to tumor progression and reduced survival rates. ROR1 contributes to these outcomes by enhancing cell proliferation, survival, invasion, epithelial-mesenchymal transition, and metastasis.
Given its role in cancer biology, ROR1 is a target for various therapeutic strategies currently under investigation for potential use in cancer treatment.
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