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Description
Invivo anti-mouse TL1A (TNFSF15) Recombinant mAbProduct Specification Host Armenian hamster Antigen TL1A (TNFSF15) Synonyms Tumor necrosis factor ligand superfamily member 15; TNF ligand related molecule 1; Vascular endothelial cell growth inhibitor; Tl1; Vegi; Tnfsf15 Location Membrane Accession Q5UBV8 Clone Number S 2750 Antibody Type Recombinant mAb Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95% by SDS PAGE Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Armenian hamster |
| Antigen | TL1A (TNFSF15) |
| Synonyms | Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; Tl1; Vegi; Tnfsf15 |
| Location | Membrane |
| Accession | Q5UBV8 |
| Clone Number | S-2750 |
| Antibody Type | Recombinant mAb |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
TL1A (TNFSF15) is a member of the tumor necrosis factor (TNF) superfamily, a group of proteins involved in various immune and inflammatory responses. TL1A is primarily expressed on antigen-presenting cells, endothelial cells, and certain epithelial cells. It functions as a ligand, binding to its receptors DR3 and HVEM, thereby modulating immune cell activation, proliferation, and survival. TL1A plays a crucial role in promoting Th1 and Th17 cell differentiation, which are key players in immune defense mechanisms. Additionally, it has been implicated in the pathogenesis of several inflammatory and autoimmune diseases, such as inflammatory bowel disease and psoriasis, where it contributes to chronic inflammation and tissue damage. Ongoing research is exploring the potential of targeting TL1A for therapeutic intervention in these conditions.
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