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Description
NDP52 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen NDP52 Synonyms Calcium binding and coiled coil domain containing protein 2; Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52 (Nuclear domain 10 protein 52); Nuclear dot protein 52; CALCOCO2 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q13137 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu Positive Sample HeLa, A549, THP 1 Purification
Product Specification
| Host | Rabbit |
| Antigen | NDP52 |
| Synonyms | Calcium-binding and coiled-coil domain-containing protein 2; Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52 (Nuclear domain 10 protein 52); Nuclear dot protein 52; CALCOCO2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | Q13137 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HeLa, A549, THP-1 |
| Purification | Immunogen Affinity |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
NDP52, also known as CALCOCO2, is a key autophagy receptor protein involved in selective autophagy processes, playing a crucial role in the recognition and degradation of invading pathogens and damaged organelles such as mitochondria. It acts as a bridge linking target substrates to autophagosomes through interactions with ubiquitinated cargos and LC3, a component of the autophagosome membrane. NDP52 is also implicated in immune signaling, where it can regulate Toll-like receptor (TLR) pathways and has been shown to mediate antiviral responses by targeting viral components for lysosomal degradation. Additionally, NDP52 has been found to interact with various proteins, including TBK1, NAP1, and Myosin VI, highlighting its multifaceted role in cellular homeostasis and defense mechanisms.
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