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Description
TBR2/Eomes Recombinant Rabbit mAb (SDT-1101-231)Product Specification Host Rabbit Antigen TBR2 Eomes Synonyms Eomesodermin homolog; T box brain protein 2 (T brain 2; TBR 2); EOMES Immunogen Synthetic Peptide Location Nucleus Accession O95936 Clone Number SDT 1101 231 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample NK 92, mouse E14 embryo brain, rat E14 embryo brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | TBR2/Eomes |
| Synonyms | Eomesodermin homolog; T-box brain protein 2 (T-brain-2; TBR-2); EOMES |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O95936 |
| Clone Number | SDT-1101-231 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NK-92, mouse E14 embryo brain, rat E14 embryo brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Ms, Rt |
Background
TBR2/Eomes is a T-box transcription factor that plays crucial roles in various developmental processes. It is preferentially enriched in intermediate progenitors and supports cortical neurogenesis expansion. In the developing cerebral cortex, it is specifically expressed in intermediate progenitors (IPs), which are derived from radial glia progenitors and generate glutamatergic projection neurons. TBR2/Eomes is essential for the differentiation and subtype specification of these neurons, and it regulates the transcriptome by activating or repressing hundreds of direct target genes. Additionally, TBR2/Eomes is involved in the formation and maintenance of certain retinal ganglion cells. It also plays a role in the maintenance of the trophectoderm lineage by sustaining chromatin accessibility and promoting gene regulatory networks.
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