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Description
Atg5 Recombinant Rabbit mAb (S-3181)Product Specification Host Rabbit Antigen Atg5 Synonyms Autophagy protein 5; APG5 like; Apoptosis specific protein; APG5L; ASP; ATG5 Location Cytoplasm Accession Q9H1Y0 Clone Number S 3181 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample PANC 1, U 87 MG, HCT 116, MCF7, HeLa, Saos 2, MEF, C2C12, C6, PC 12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | Atg5 |
| Synonyms | Autophagy protein 5; APG5-like; Apoptosis-specific protein; APG5L; ASP; ATG5 |
| Location | Cytoplasm |
| Accession | Q9H1Y0 |
| Clone Number | S-3181 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | PANC-1, U-87 MG, HCT 116, MCF7, HeLa, Saos-2, MEF, C2C12, C6, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
Autophagy-related protein 5 (ATG5), encoded by the ATG5 gene on chromosome 6, is a core autophagy protein that forms a complex with ATG12 and ATG16L1 (the Atg12-Atg5-Atg16 complex), which is essential for lipidation of LC3 (microtubule-associated protein 1 light chain 3B) and subsequent autophagosome elongation and maturation. Beyond autophagy, ATG5 also has non-autophagic roles, including promoting apoptosis via mitochondrial translocation and cytochrome c release, regulating immune responses (e.g., antigen presentation and lymphocyte development), and affecting hematopoietic stem cell maintenance. ATG5 deficiency (e.g., in knockout mice) is neonatal lethal, causing autophagy defects, neurodegeneration, and impaired fertility, while its overexpression extends lifespan. Additionally, ATG5 mutations are linked to human diseases (e.g., ataxia), and it plays a role in viral infections (e.g., HIV-1) by modulating host antiviral responses.
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