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Description
Alexa Fluor® 488 Mouse Anti-Human CD107a Antibody (S-3027)Product Specification Host Mouse Antigen CD107a Synonyms Lysosome associated membrane glycoprotein 1; LAMP 1; Lysosome associated membrane protein 1 Curated; CD107 antigen like family member A; LAMP1 Location Cell membrane Accession P11279 Clone Number S 3027 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Jurkat Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid
Product Specification
| Host | Mouse |
| Antigen | CD107a |
| Synonyms | Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1 Curated; CD107 antigen-like family member A; LAMP1 |
| Location | Cell membrane |
| Accession | P11279 |
| Clone Number | S-3027 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Jurkat |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD107a, also termed lysosome-associated membrane protein-1 (LAMP-1), is a heavily glycosylated type-I transmembrane glycoprotein encoded by the LAMP1 gene, constituting ~50 % of all proteins in the lysosomal membrane where its dense carbohydrate coat protects against self-digestion, while in immune cells it functions as a universally accepted surrogate marker of cytotoxic degranulation because, upon NK- or CD8⁺ T-cell activation, the lytic granules fuse with the plasma membrane and transiently expose CD107a on the cell surface, enabling flow-cytometric quantification of perforin/granzyme release; beyond immunology, CD107a shuttles between lysosomes, endosomes and the plasma membrane, provides carbohydrate ligands for selectins to facilitate leukocyte adhesion, and its overexpression on tumor cells correlates with enhanced metastatic potential .
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