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Description
VE-Cadherin Recombinant Rabbit mAb (S-3312-5)Product Specification Host Rabbit Antigen VE Cadherin Synonyms Cadherin 5; 7B4 antigen; Vascular endothelial cadherin (VE cadherin); CD144; CDH5 Immunogen Synthetic Peptide Location Cell membrane, Cell junction Accession P33151 Clone Number S 3312 5 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample bEnd. 3, mouse lung, rat lung, rat heart Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | VE-Cadherin |
| Synonyms | Cadherin-5; 7B4 antigen; Vascular endothelial cadherin (VE-cadherin); CD144; CDH5 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cell junction |
| Accession | P33151 |
| Clone Number | S-3312-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | bEnd.3, mouse lung, rat lung, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
Background
VE-Cadherin (vascular endothelial cadherin, CDH5) is a 140-kDa transmembrane glycoprotein that forms the core of endothelial adherens junctions, where its calcium-dependent homophilic interactions between extracellular EC1-EC5 repeats create a semi-permeable barrier between blood and tissues; its cytoplasmic tail recruits β-catenin, plakoglobin and p120-catenin, linking the junction to the actin cytoskeleton and enabling transmission of shear-stress signals that regulate angiogenesis, vascular remodeling and leukocyte extravasation, while phosphorylation of Y685 and Y658 by Src, VEGFR2 or Tie-2 and subsequent internalization of the complex transiently increases permeability during inflammation, tumor metastasis and atherosclerosis, making VE-cadherin a key therapeutic target in vascular pathologies.
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Exchange/Return Notes
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