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Description
GAD2 His&GST Tag Protein, HumanProduct Specification Species Human Synonyms Glutamate decarboxylase 2, GAD 65, GAD2 Accession Q05329 Amino Acid Sequence Met1 Leu585, with N terminal His and GST Expression System Baculovirus InsectCells Molecular Weight 93kDa (Reducing) Purity 90% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag, GST Tag Physical Appearance Liquid Storage Buffer 20mM Tris,500mM NaCl,10%,glycerol,3mM DTT,pH8. 0. Stability & Storage 12 months from
Product Specification
| Species | Human |
| Synonyms | Glutamate decarboxylase 2, GAD-65, GAD2 |
| Accession | Q05329 |
| Amino Acid Sequence | Met1-Leu585, with N-terminal His and GST |
| Expression System | Baculovirus-InsectCells |
| Molecular Weight | 93kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag, GST Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 20mM Tris,500mM NaCl,10%,glycerol,3mM DTT,pH8.0. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Karlsen A.E., et al.,(1991), Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl. Acad. Sci. U.S.A. 88:8337-8341. 2.Bu D.-F., et al., (1992), Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.Proc. Natl. Acad. Sci. U.S.A. 89:2115-2119. 3.Bu D.-F., et al.,(1994), The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.Genomics 21:222-228. |
Background
Glutamate decarboxylase is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoantigen in insulin-dependent diabetes. It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid.GAD2 also is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake and play a role in the stiff man syndrome.
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