SKU: 37155774711

Alexa Fluor® 488 Mouse Anti-Human CD45 Antibody (S-3269)

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Description

Alexa Fluor® 488 Mouse Anti-Human CD45 Antibody (S-3269)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; PTPRC Location Cell membrane, Synapse Accession P08575 Clone Number S 3269 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human peripheral blood Leukocytes Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; PTPRC
Location Cell membrane, Synapse
Accession P08575
Clone Number S-3269
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD45, also known as protein tyrosine phosphatase receptor type C (PTPRC), is a crucial transmembrane glycoprotein expressed on the surface of all nucleated hematopoietic cells except erythrocytes and plasma cells. It is a receptor-like protein tyrosine phosphatase that plays a vital role in regulating immune cell activation and differentiation. CD45 consists of an extracellular domain, a transmembrane segment, and intracellular phosphatase domains. Its primary function is to dephosphorylate specific tyrosine residues on target proteins, thereby modulating signaling pathways essential for immune responses. CD45 has multiple isoforms generated by alternative splicing, which are differentially expressed across immune cell subsets and influence their activation thresholds. For example, naïve T cells predominantly express CD45RA, while memory T cells express CD45RO, which enhances T-cell receptor signaling. In pathology, CD45 is used as a marker to identify hematopoietic cells and distinguish lymphomas from other types of cancer.

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SKU: 37155774711

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4.2 ★★★★★
Based on 5 reviews
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Product Reviews
M
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Mamachills
Phoenix, US
★★★★★ 4
they are indestructible
Color: Real Bacon&Beef
these chews can definitely stand up to an aggressive chewer. they are extremely hard and will probably last for months, maybe a year or more. but because they are so indestructible, they are the last of the chew toys that my pitbull will go for. i appreciate that he will sometimes tackle one for a while. he prefers the hardest rubber kong-type chew toys. they are not indestructible, but it takes a while for him to wear them down and destroy them. i will probably not buy these indestructible chews again (bought 2-3 packages already), but if you have a big headed dog with lots of really strong teeth and jaws like a vice, they might be right for your pet.
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Reviewed in the United States on May 21, 2026
A
Verified Purchase
Annabelle
Lake Worth, US
★★★★★ 5
My dog loves them
Color: Real Bacon&Beef, Color: Real Bacon&Beef
Got yesterday, and my dog already did some damage to them; however it isn't enough damage to make the toys unsafe and unusable. So far they have lasted longer than any of her other toys (a full 24 hours already). So when the time comes that she needs some new toys, we are definitely going to be purchasing these again, she loves them.
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Reviewed in the United States on June 6, 2026
B
Verified Purchase
brownie2009
Birmingham, US
★★★★★ 3
These are adorable
Color: Coffe Wood, Color: Coffe Wood
This little frozen treat kit is absolutely adorable. I found 3 different colors for my 3 dogs, so I can tell who got theirs stolen. First, the kit itself is a 5 star. The little skull, the brain mold, absolutely adorable. Second, as with a lot of other reviews, what is up with the rope? I had hoped there was a cover for that part of the skull heads when I bought them, then I double checked the reviews and could have had a V8. 🤦🏼‍♀️ the good news is that once you get the rope off you can replace it with something more washable, if you choose. Rope is a 2 to 3 star. Third, my dogs don't like these ones as much, that's why the 3 stars. They've tried out 3 different kinds, with a 4th one coming this week. This was their 3rd favorite. They like the ability to carry it by the rope. Getting to the treat through the hole in the bottom isn't "hard", but the skull is tilted on the side, which is exactly what you want to keep your dog entertained, but two of my dogs didn't want to deal with it unless I held it for them. 😒 Dramatic. Fourth, and finally, I am keeping them. I will probably not put frozen treats in them again, and use it for dry treats or something. So, 3 to 4 stars since I probably won't be able to use the mold for these unless the dogs get used to them. These little skills have more of a rubber texture to them, making them not really hard plastic, and seemingly more durable. The top, so far, is easy to take off, if you don't have wet hands. There's little divets in the top to help you screw and unscrew thw top. Be careful not to screw it on too tight or too loose. I would take it away from my dogs as soon as I notice they are done with their treats, as I would with dirty dishes. It isn't a toy-toy, more like a treat dispenser.
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Reviewed in the United States on July 13, 2025
M
Verified Purchase
Matt
Boise, US
★★★★★ 5
Ruff and rugged
Color: Real Bacon&Beef
Ruff and rugged, my dogs chew through everything we get them, not this so far, holding up well against the aggressive chewers.
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Reviewed in the United States on May 18, 2026
S
Verified Purchase
Shea Milligan
Chelsea, US
★★★★★ 4
Has some flaws but overall not bad
Color: Coffe Wood
I have a 13 pound Jack Russell mix who is an aggressive chewer and gets bored while I am working. I find that a frozen treat situation keeps him busy for 30-45 minutes in his kennel so I can get some quiet time. I've been stuffing the Kong and freezing it, but since I only have one, I have to remember to do it. I liked the option of keeping a bunch of frozen treats to refill the toy at will. I've been eyeballing the Pupsicle brand, but they are really expensive. So for around $10, I figured this was worth a try. Pros: So far seems tough. I unscrew it after he finishes the frozen treat so he can lick out the remains, then I take it away from him. I'm sure if I let him he would eventually chew it to shreds. The design is cute. Although you can't see the fact that the treats are brain shaped once it is in there, it does give me a kick to put a little brain in the skull. So far no issues with screwing the top of the skull on or taking it off The inner cavity is quite big. I filled the molds about 3/4 full and there is still a lot of room in the skull. If you have a bigger dog you can fill the molds to the top (just don't over-fill or it won't fit inside) If you make a big batch of treat filling, you can freeze the rest in those silicone muffin molds, they fit perfectly. Just don't over-fill. With a 3/4 full mold, made with pumpkin, peanut butter, oats, and a little water, it takes my dog about 45 minutes to get all of the treat out. Cons: It's huge and heavy. It's bigger than my dog's skull. But, since he is just trying to eat the brains, it's not like it needs to be lightweight. The rope is a bad idea. First, it gets gross. Second, my dog has chewed halfway through it already. This seems like a hazard for both choking and bacterial contamination. The biggest hole is big enough that my dog's bottom jaw gets a little stuck in there. So far he's always able to get it out, but it is a point against the toy. Overall, its not bad. Not perfect, but serves the function. I'd like to see a slightly smaller, slightly lighter version for dogs under 20 pounds, and lose the rope. If you do buy this, make sure to take it away from your dog once they have cleaned out the treat.
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Reviewed in the United States on June 5, 2025

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