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Description
CD112R Recombinant Rabbit mAb (S-1923-22)Product Specification Host Rabbit Antigen CD112R Synonyms Transmembrane protein PVRIG; CD112 receptor (CD112R); Poliovirus receptor related immunoglobulin domain containing protein; C7orf15; PVRIG Immunogen Recombinant Protein Location Cell membrane Accession Q6DKI7 Clone Number S 1923 22 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample Jurkat, Daudi, Ramos Purification Protein A Concentration 1 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | CD112R |
| Synonyms | Transmembrane protein PVRIG; CD112 receptor (CD112R); Poliovirus receptor-related immunoglobulin domain-containing protein; C7orf15; PVRIG |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q6DKI7 |
| Clone Number | S-1923-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Jurkat, Daudi, Ramos |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CD112R, also known as PVRIG, is a co-inhibitory receptor belonging to the poliovirus receptor (PVR) family. It is a 36kD single-pass transmembrane protein composed of one transmembrane domain, a long intracellular domain, and a single extracellular immunoglobulin variable-like (IgV) domain. CD112R is predominantly expressed on natural killer (NK) cells and T cells, especially CD8+ T cells, and its expression is upregulated upon activation. In the tumor microenvironment, CD112R is highly expressed on NK cells, CD4+ T cells, and CD8+ T cells. It binds to its ligand CD112 (NECTIN2 or PVRL2) with high affinity, inhibiting the activation of T cells and NK cells, thus contributing to immune evasion in cancer. This makes the CD112R/CD112 axis a potential target for cancer immunotherapy.
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