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Description
USP14 ProteinProduct Specification Species Human Synonyms Ubiquitin carboxyl terminal hydrolase 14,Deubiquitinating enzyme 14,Ubiquitin thioesterase 14,Ubiquitin specific processing protease 14 Accession P54578 Amino Acid Sequence Q96 Q494 end Expression System E. coli Molecular Weight 47. 6 KDa Purity 95% by SDS PAGE Endotoxin <0. 01EU g Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50 mM Tris HCl (pH 7. 5), 250 mM NaCl, 5%
Product Specification
| Species | Human |
| Synonyms | Ubiquitin carboxyl-terminal hydrolase 14,Deubiquitinating enzyme 14,Ubiquitin thioesterase 14,Ubiquitin-specific-processing protease 14 |
| Accession | P54578 |
| Amino Acid Sequence |
Q96-Q494 end
|
| Expression System | E.coli |
| Molecular Weight | 47.6 KDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.01EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50 mM Tris-HCl (pH 7.5), 250 mM NaCl, 5% glycerol. |
| Stability & Storage |
Stable for up to twelve months from date of receipt at -80℃.
|
Background
Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation. USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome. Increasing evidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, and viral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets,USP14 has garnered widespread interest as a therapeutic target.
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