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Description
OX40L Recombinant Rabbit mAb (S-2597-17)Product Specification Host Rabbit Antigen OX40L Synonyms Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand (OX40L); TAX transcriptionally activated glycoprotein 1; CD252; TXGP1; TNFSF4 Immunogen Synthetic Peptide Location Membrane Accession P23510 Clone Number S 2597 17 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HUVEC Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | OX40L |
| Synonyms | Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand (OX40L); TAX transcriptionally-activated glycoprotein 1; CD252; TXGP1; TNFSF4 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | P23510 |
| Clone Number | S-2597-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HUVEC |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
OX40L (also called CD252 or TNFSF4) is a type-II transmembrane glycoprotein of the TNF superfamily that is chiefly expressed on antigen-presenting cells such as dendritic cells, B cells and macrophages; when it engages its receptor OX40 (CD134) on recently activated CD4⁺ and CD8⁺ T cells it delivers a potent co-stimulatory signal that triggers TRAF-dependent cascades (PI3K–Akt, NF-κB1), thereby amplifying T-cell proliferation, survival, cytokine secretion and memory formation, a mechanism exploited experimentally by OX40L agonists to boost anti-tumor immunity and targeted therapeutically by blocking agents to dampen harmful inflammation in autoimmunity and allergic diseases.
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