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Description
CD138 IHCstart KitProduct Specification Application IHC P Reactivity Hu Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage Primary antibody: 12 months from date of receipt reconstitution, 20 C as supplied IHC detection kit: 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution species IHC 1: 1000 Background Syndecan 1 (CD138) is mostly restricted to epithelia, and
Product Specification
| Application | IHC-P |
| Reactivity | Hu |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | Primary antibody:12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:1000 |
Background
Syndecan-1 (CD138) is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides, including extracellular matrix components and potent mediators of proliferation, adhesion and migration. For this reason, it has been studied extensively with respect to carcinomas and tumor progression. Frequently, but not always, syndecan-1 levels decrease as tumor grade, stage and invasiveness and dedifferentiation increase. However, in some tumors, levels of syndecan-1 increase, but the characterization of its distribution is relevant. There can be loss of membrane staining, but acquisition of cytoplasmic and/or nuclear staining that is abnormal. Moreover, the appearance of syndecan-1 in the tumor stroma, either associated with its cellular component or the collagenous matrix, is nearly always a sign of poor prognosis [PMID: 33921767]. The reagent can complete 50 slides for IHC experiment and the primary antibody is excessive.
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