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Description
GPC3/Glypican 3 His Tag Protein, MouseProduct Specification Species Mouse Synonyms GPC3, OCI5, Glypican 3, GTR2 2, MXR7, DGSX, SDYS Accession Q8CFZ4 Amino Acid Sequence Gln25 Met557, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | GPC3, OCI5, Glypican-3, GTR2-2, MXR7, DGSX, SDYS |
| Accession | Q8CFZ4 |
| Amino Acid Sequence | Gln25-Met557, with C-terminal 10*His QPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQMMNPGLPESVLDINECLRGARRDLKVFGSFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNGGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKILKVAHVEHEETLSSRRRELIQKLKSFINFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSVPKGKVLDKSLDEEGLESGDCGDDEDECIGSSGDGMVKVKNQLRFLAELAYDLDVDDAPGNKQHGNQKDNEITTSHSVGNMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 72-130kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Kandil D H. et al. (2009) Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 16(2): 125-129. 2、Maeda D. et al. (2009) Glypican-3 expression in clear cell adenocarcinoma of the ovary. Mod Pathol. 22(6): 824-832. |
Background
Glypican-3 (GPC3) belongs to a six-member family of membrane-bound heparan sulfate proteoglycans with a gene that is localized to Xq26.2. GPC3 belongs to a family of Glypicans are heparan sulfate proteoglycans that are bound to the cell surface by glycosyl phosphatidyli nositol. While six members of the glypican family are known in mammals, our study focused on glypican 3(GPC3). Loss-of-function mutations of GPC3 result in the Simpson- Golabi-Behmel syndrome, an X-linked disorder characterized by pre- and postnatal liver and other organ overgrowth. GPC3 is overexpressed in human hepatocellular carcinoma; however, its role in normal liver regeneration and hepatocyte proliferation is unknown. GPC3 is located on the X chromosome, and is highly expressed during embryogenesis and organogenesis. In the adult, on the other hand, GPC3 can only be detected in a limited number of tissues, including the lung, ovaries, mammary epithelium and mesothelium.
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4.1 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 5
Great for a chewer
Color: Dogwood (Brown), Size: Large (Pack of 1)
My dog loves a hard toy and a durable one. My dog has been chewing on this for months and it is still holding strong. Because it is a hard toy when my dog brings this into another room with a hard floor and drops the toy it can be startling. My dog will choose this toy over others on a daily basis and brings the toy to other rooms.
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Reviewed in the United States on May 19, 2026
★★★★★ 5
Durable
Color: Dogwood (Brown), Size: Large (Pack of 1)
Durable, good chew toy.
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Reviewed in the United States on June 8, 2026
★★★★★ 5
GREAT TOY
Color: Dogwood (Brown), Size: Large (Pack of 1)
My 6m old Shepard Terrier LOVES this toy. He loves chewing on wood and we’ve gotten him all types of chew toys but I’ve never seen any toy keep him this busy and interested. Buy if ur dog chews furniture!!!!
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Reviewed in the United States on June 13, 2026
★★★★★ 4
Large is a little big for Bostons
Color: Dogwood (Brown), Size: Large (Pack of 1)
Seems to be durable for 2 VERY agressive chewer Boston Terriers. Cricket and Alice are shockingly good at chewing - grateful they pick to do so with thier toys.
Trial vs other name brand competitor.
PetStages' is a little larger so harder to bite on fir small dogs, but seems to be equally durable. While PetStages proudly states it has real wood fiber and scent (whoch I thought would win)... they prefered the other. Both dogs love to chew on real sticks.
But, when the bossy one indicated she was taking over the stick the other dog had, they exchanged, and kept chewing, over and over, back and forth. I mean to say, whatever the prefered stick was at first didnt seem to matter later.
These super hard chew toys do make me nervous. One dog broke a tooth last summer on a different brand toy, a very expensive extraction bill, and poor pup's terrible discomfort... but the other did not and has amazing white teeth, all around.... so.
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Reviewed in the United States on September 26, 2025
★★★★★ 5
Great for teething puppies
Color: Dogwood (Brown), Size: Small (Pack of 1)
My pup absolutely loves this. Can keep him occupied for up to 45 min at a time. Pretty durable, too.
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Reviewed in the United States on May 8, 2026