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Description
SFRP1 Recombinant Rabbit mAb (S-3071-18)Product Specification Host Rabbit Antigen SFRP1 Synonyms Secreted frizzled related protein 1; FRP 1; sFRP 1; Secreted apoptosis related protein 2 (SARP 2); FRP; FRP1; SARP2 Immunogen Synthetic Peptide Location Secreted Accession Q8N474 Clone Number S 3071 18 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A549, SK MEL 28 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | SFRP1 |
| Synonyms | Secreted frizzled-related protein 1; FRP-1; sFRP-1; Secreted apoptosis-related protein 2 (SARP-2); FRP; FRP1; SARP2 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | Q8N474 |
| Clone Number | S-3071-18 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A549, SK-MEL-28 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
Background
SFRP1 (Secreted Frizzled-Related Protein 1) is a 313-amino-acid, cysteine-rich antagonist of Wnt signaling that is secreted into the extracellular space where it binds Wnt ligands and Frizzled receptors to modulate β-catenin–dependent and –independent pathways, thereby regulating embryonic segmentation, eye, heart and bone development, as well as adult tissue homeostasis, while its epigenetic or mutational silencing in cancers removes this brake on Wnt signaling and drives tumor progression, invasion and metastasis.
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Exchange/Return Notes
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