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Description
CHI3L1 Recombinant Rabbit mAb (S-324-38)Product Specification Host Rabbit Antigen CHI3L1 Synonyms Chitinase 3 like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39 (CGP 39; GP 39; hCGP 39), YKL 40 Immunogen Recombinant Protein Location Cytoplasm, Secreted Accession P36222 Clone Number S 324 38 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CHI3L1 |
| Synonyms | Chitinase-3-like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39 (CGP-39; GP-39; hCGP-39), YKL-40 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Secreted |
| Accession | P36222 |
| Clone Number | S-324-38 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:50-1:400 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
Chitinase-3 like-protein-1 (CHI3L1), one of the CLPs, also has been named YKL-40 in humans and breast regression protein 39 (BRP-39) in mice, is common in both prokaryotes and eukaryotes. Following its initial discovery in the culture supernatant of the osteosarcoma cell line MG63, it was subsequently detected in human chondrocytes, synoviocytes, and vascular smooth muscle cells. In fact, CHI3L1 is produced by a multitude of cells, including macrophages, neutrophils, fibroblast-like cells, hepatic stellate cells, endothelial cells, and cancer cells. CHI3L1 is overexpressed in many human cancer types and animal tumor models, for instance, oligodendroglia, glioblastoma, osteosarcoma, sarcoma, colon, and gastric cancers (GCs). Elevated serum levels of CHI3L1 have been found to be associated with poor prognosis and shorter survival in patients with metastatic cancer. Consequently, CHI3L1 has been increasingly proposed as a sensitive biomarker and an attractive therapeutic target for several certain types of cancers.
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