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Description
MICA His Tag Protein, HumanProduct Specification Species Human Synonyms FLJ60820; MGC111087; PERB11. 1 Accession Q29983 Amino Acid Sequence Glu24 Gln308, with C terminal His Expression System HEK293 Molecular Weight 50 70kDa (Reducing) Purity 95% by SDS PAGE & RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | FLJ60820; MGC111087; PERB11.1 |
| Accession | Q29983 |
| Amino Acid Sequence | Glu24-Gln308, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Journal List J Immunother Cancer v.7; 2019 . |
Background
MICA, a 383-amino-acid protein, interacts with the NKG2D receptor and the T cell receptor (TCR) to stimulate the activation of natural killer (NK) cells, αβ CD8 T cells, and γδ T cells. Typically undetectable in most cells, MICA is frequently found in epithelial tumors and its expression can be triggered by both bacterial and viral infections. The interaction between MICA and NKG2D leads to the activation of cytolytic functions and cytokine production in these effector cells, playing a crucial role in tumor surveillance, defense against viral infections, and the modulation of autoimmune responses.
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