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Description
PSMA/FOLH1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP Accession Q04609 1 Amino Acid Sequence Lys44 Ala750 , with N terminal Fc Expression System HEK293 Molecular Weight 110 140kDa (Reducing) Purity >95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml
Product Specification
| Species | Human |
| Synonyms | GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP |
| Accession | Q04609-1 |
| Amino Acid Sequence | Lys44-Ala750 , with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 110-140kDa (Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Su S L. et al. (1995) Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression. Cancer Res. 55: 1441-1443. |
Background
Prostate-Specific Membrane Antigen (PSMA) is a transmembrane protein that is consistently found in prostatic tissues. Its expression is notably elevated in various malignancies, with prostate cancer exhibiting particularly high levels. In nearly all cases of prostate adenocarcinoma, PSMA is expressed in the majority of both primary and metastatic lesions.
Immunohistochemical analysis has shown that PSMA expression intensifies in patients with dedifferentiated, metastatic, or hormone-refractory tumors. The level of PSMA expression has been correlated with the prognosis of the disease, offering significant predictive value for patient outcomes.
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