SKU: 26650350048

pro Caspase-1 + p10 + p12 Recombinant Rabbit mAb (S-3500)

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Description

pro Caspase-1 + p10 + p12 Recombinant Rabbit mAb (S-3500)Product Specification Host Rabbit Antigen pro Caspase 1 + p10 + p12 Synonyms Caspase 1; CASP 1; Interleukin 1 beta convertase (IL 1BC); Interleukin 1 beta converting enzyme (ICE; IL 1 beta converting enzyme); p45; IL1BC; IL1BCE; CASP1 Location Cytoplasm, Cell membrane Accession P29466 Clone Number S 3500 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample THP 1, NK 92, RAW264. 7, J774A. 1, mouse spleen, mouse

Product Specification


Host Rabbit
Antigen pro Caspase-1 + p10 + p12
Synonyms Caspase-1; CASP-1; Interleukin-1 beta convertase (IL-1BC); Interleukin-1 beta-converting enzyme (ICE; IL-1 beta-converting enzyme); p45; IL1BC; IL1BCE; CASP1
Location Cytoplasm, Cell membrane
Accession P29466
Clone Number S-3500
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample THP-1, NK-92, RAW264.7, J774A.1, mouse spleen, mouse lung, rat spleen, rat lung
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms, Rt

Background

Pro Caspase-1 is a 45 kDa inactive zymogen that, upon assembly of the canonical inflammasome, undergoes autoproteolysis between the p20 and p10 subunits, releasing an N-terminal CARD domain, the p20 subunit, and the p10 subunit; the resulting heterotetramer of two p20 and two p10 chains (often described as p20-p10 plus the additional p12 peptide that can remain non-covalently associated) forms the active caspase-1 protease, which subsequently cleaves pro-IL-1β and pro-IL-18 to drive inflammatory responses.

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SKU: 26650350048

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4.6 ★★★★★
Based on 22 reviews
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Product Reviews
C
Verified Purchase
Carmen Alicea
Pawtucket, US
★★★★★ 5
A Beta Worth Rooting For
Format: Kindle
In Spare, Violet Fox flips the omegaverse on its head, giving us a Beta heroine determined to make her mark. Joining the Beta Trials to support her sick father, she's thrown into a pack that doesn't want her, especially the possessive Alphas. But here's the twist: their sweet Omega turns out to be her scent match. Cue the angst, forbidden tension, and a slow-burn romance that will make your heart ache in the best way. Violet Fox delivers an emotional, refreshing take on the genre, proving Betas aren't "spares." They're stars.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 10, 2025
C
Verified Purchase
C. Hunter
San Leandro, US
★★★★★ 5
Beta, Alpha, Omega oh my!
Format: Kindle
Omegas are precious and given to Alphas & their packs... but the Betas want in too. To this end, the Beta government is rolling out its trial of assigning a Beta to each Alpha-Omega pack. But forcing a Beta into a pack where they are not wanted will not end well... Of course, no one expected the Omega to fall for the assigned Beta. Great read and cliffhanger
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2025
B
Verified Purchase
B. Stubby
Waukegan, US
★★★★★ 3
A familiar story, just with…..less.
Format: Kindle
So, as other reviewers make clear, this is very similar to Pack Darling and The Beta. It’s much closer aligned with The Beta, in plot and maybe more like Pack Darling with characters. That being said, I don’t hate this…..but it wasn’t great either. It’s both books mentioned but just….less. Less angst, less emotion, less feeling. The plot feels very half fleshed out, and the “bad guy” feels underwhelming. I didn’t really feel any real emotions from and of the male leads, except maybe Oliver. The others fell sorta flat for me. And Mika makes herself out to be this big bad ass straight outta training and then we never see it from here again with the one fitting room incident as the exception. SPOILER: The whole, “Oh, I’m actually probably an Omega, but I don’t wanna be but I do actually wanna be but no one can ever know my secret that I do nothing to hide “ thing fell so flat. She never commutes to believing she was secretly an omega, but also mentions her “secret” a lot. It just felt so manufactured. I’m intrigued enough to read part 2 and see how the author closes everything out, but this is not one I’ll recommend or ever come back to.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 13, 2024
S
Verified Purchase
SR
Lexington, US
★★★★★ 5
Good start to a series
Format: Kindle
I delayed reading the series for reasons I don’t remember. But my TBR list is huge so I thought I’d take a shot of this and I was pleasantly surprised. I didn’t think the blurb about it was anything special. But it was a very good book. It took some interesting twists and turns. I am so glad the second book is already out. Because I would not have waited patiently. Very slow burn but good storyline. 🔥🔥/5
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Reviewed in the United States on January 3, 2025
J
Verified Purchase
Jammie Clark
Alexandria, US
★★★★★ 4
A good read
Format: Kindle
Multiple points of view. 3 Alpha men and an Omega male. She is a Beta in training for a new program placing betas in Alpha/Omega packs. Mila is only doing the program for the money to take care of her dad. She wasn't expecting to fall for a pack but when she sees this packs Omega she is done for. There is just something about him. His Alphas are good looking as well. Too bad she is hiding a secret and their government is acting shady. I liked it and can't wait to see where their story goes.
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Reviewed in the United States on November 14, 2023

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