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Description
Sialoadhesin/CD169 Recombinant Rabbit mAb (SDT-3228-8)Product Specification Host Rabbit Antigen CD169 Synonyms Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid binding Ig like lectin 1 (Siglec 1); Sa; Sn; Siglec1 Immunogen Recombinant Protein Location Cell membrane Accession Q62230 Clone Number SDT 3228 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample PMA, LPS and BFA treated THP 1 cells, LPS treated RAW264. 7, mouse spleen, mouse
Product Specification
| Host | Rabbit |
| Antigen | CD169 |
| Synonyms | Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid-binding Ig-like lectin 1 (Siglec-1); Sa; Sn; Siglec1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q62230 |
| Clone Number | SDT-3228-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | PMA, LPS and BFA treated THP-1 cells, LPS treated RAW264.7, mouse spleen, mouse liver, rat spleen, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the immunoglobulin superfamily expressed predominantly on subsets of tissue-resident macrophages and some dendritic cells; it contains 17 extracellular Ig-like domains that together project ~33 nm from the plasma membrane to enable high-avidity binding to α2,3-linked sialic acid moieties on glycoproteins and glycolipids of host cells or pathogens, thereby facilitating pathogen capture, antigen presentation, and adaptive immune priming while simultaneously serving as an entry portal for viruses such as HIV-1, PRRSV, and SARS-CoV-2, and its interferon-inducible expression correlates with both protective immunity and disease severity in infections, cancer, and chronic inflammatory disorders.
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