Pay in installments of $42.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 6 - Sep 11
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Alexa Fluor® 488 Armenian hamster Anti-Mouse CD3 Antibody (S-R491)Product Specification Host Armenian hamster Antigen CD3 Synonyms T cell surface glycoprotein CD3 zeta chain; T cell receptor T3 zeta chain; Cd3z; Tcrz; Cd247 Location Cell membrane Accession P24161 Clone Number S R491 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Armenian hamster |
| Antigen | CD3 |
| Synonyms | T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain; Cd3z; Tcrz; Cd247 |
| Location | Cell membrane |
| Accession | P24161 |
| Clone Number | S-R491 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD3, also known as the cluster of differentiation 3, is a protein complex found on the surface of T cells, playing a crucial role in the immune system. It consists of four distinct chains: CD3γ, CD3δ, CD3ε, and CD3ζ. These chains form a complex that associates noncovalently with the T-cell receptor (TCR) to form the TCR complex, which is essential for recognizing antigens presented by major histocompatibility complex (MHC) molecules. When the TCR binds to an antigen-MHC complex, the CD3 complex transmits signals into the T cell, initiating a cascade of intracellular events that lead to T cell activation, proliferation, and differentiation. This process is vital for the immune response against pathogens and abnormal cells. CD3 is also involved in T cell development and maturation in the thymus. Given its central role in T cell function, CD3 is a key target in immunotherapy for diseases such as cancer and autoimmune disorders.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy