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Description
Alexa Fluor® 647 Mouse Anti-Human CD106 Antibody (S-2895)Product Specification Host Mouse Antigen CD106 Synonyms Vascular cell adhesion protein 1; V CAM 1; VCAM 1; INCAM 100; VCAM1 Location Secreted, Cell membrane Accession P19320 Clone Number S 2895 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HUVEC treated with TNF Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD106 |
| Synonyms | Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; INCAM-100; VCAM1 |
| Location | Secreted, Cell membrane |
| Accession | P19320 |
| Clone Number | S-2895 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HUVEC treated with TNF-α |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD106, also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein encoded by the VCAM1 gene in humans and belongs to the immunoglobulin superfamily. It is a cytokine-inducible cell surface protein that mediates the adhesion of leukocytes to vascular endothelium, playing a crucial role in immune responses and inflammation. CD106 is primarily expressed on endothelial cells, but its expression can also be found in other cell types such as smooth muscle cells and mesenchymal stem cells. The upregulation of CD106 in endothelial cells is induced by cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), and it is involved in various pathological conditions, including atherosclerosis and rheumatoid arthritis. In addition, CD106 is essential for embryonic development, particularly in the formation of the umbilical cord and placenta.
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