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Description
Alexa Fluor® 647 Mouse Anti-Rat CD68 Antibody (S-R674)Product Specification Host Mouse Antigen CD68 Synonyms Cd68 Location Lysosome, Endosome, Cell membrane Accession Q4FZY1 Clone Number S R674 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Rt Positive Sample SD Rat peritoneal exudates cells Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | CD68 |
| Synonyms | Cd68 |
| Location | Lysosome, Endosome, Cell membrane |
| Accession | Q4FZY1 |
| Clone Number | S-R674 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Rt |
| Positive Sample | SD Rat peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1.25μl per million cells in 100μl volume | Rt |
Background
CD68, also known as macrosialin in mice, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the lysosome-associated membrane protein family. It is predominantly expressed in cells of the monocyte lineage, such as macrophages, microglia, and osteoclasts. CD68 serves as a reliable marker for these immune cells and plays a crucial role in various immunological processes. It is primarily located within lysosomes and endosomes but can also be found on the cell surface. CD68 is involved in phagocytosis, antigen presentation, and the clearance of cellular debris and pathogens. In addition, it has been implicated in the regulation of bone resorption and may serve as a receptor for malaria sporozoite in liver infection. In the context of cancer, CD68 expression is often used as a prognostic marker, with higher numbers of CD68-positive tumor-associated macrophages correlating with worse outcomes in some studies.
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