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Description
DRP1 Recombinant Rabbit mAb (S-1927-27)Product Specification Host Rabbit Antigen DRP1 Synonyms Dynamin 1 like protein; Dnm1p Vps1p like protein (DVLP); Dynamin family member proline rich carboxyl terminal domain less (Dymple); Dynamin like protein; Dynamin like protein 4; Dynamin like protein IV (HdynIV); Dynamin related protein 1; DLP1; DNM1L Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion, Endoplasmic reticulum Accession O00429 Clone Number S 1927 27 Antibody Type
Product Specification
| Host | Rabbit |
| Antigen | DRP1 |
| Synonyms | Dynamin-1-like protein; Dnm1p/Vps1p-like protein (DVLP); Dynamin family member proline-rich carboxyl-terminal domain less (Dymple); Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV (HdynIV); Dynamin-related protein 1; DLP1; DNM1L |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion, Endoplasmic reticulum |
| Accession | O00429 |
| Clone Number | S-1927-27 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, HCT 116, NIH/3T3, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
Dynamin-related protein 1 (DRP1) is a cytoplasmic GTPase protein encoded by the DNM1L gene, playing a crucial role in mediating mitochondrial fission. Under normal conditions, DRP1 resides in the cytoplasm and is recruited to the mitochondrial outer membrane upon activation, where it forms spiral oligomers that constrict and divide the mitochondria. This process is regulated by various post-translational modifications, such as phosphorylation at serine 616, which enhances DRP1 activity and promotes mitochondrial fission. DRP1 is essential for maintaining mitochondrial dynamics, cell survival, and energy metabolism, and its dysregulation has been implicated in a range of diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases.
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