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Description
YTHDC2 Recombinant Rabbit mAb (S-3338-41)Product Specification Host Rabbit Antigen YTHDC2 Synonyms 3' 5' RNA helicase YTHDC2; YTH domain containing protein 2 (hYTHDC2) Immunogen Synthetic Peptide Location Cytoplasm Accession Q9H6S0 Clone Number S 3338 41 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample K562, HeLa, HEK 293, HT 1080, NIH 3T3, Neuro 2a, C6, PC 12, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | YTHDC2 |
| Synonyms | 3'-5' RNA helicase YTHDC2; YTH domain-containing protein 2 (hYTHDC2) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q9H6S0 |
| Clone Number | S-3338-41 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | K562, HeLa, HEK-293, HT-1080, NIH/3T3, Neuro-2a, C6, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
YTHDC2 is an RNA-binding protein that specifically recognizes N6-methyladenosine (m6A) modifications on mRNA, functioning as a critical regulator of post-transcriptional gene expression by facilitating mRNA splicing, export, and degradation through its conserved YTH domain, with essential roles in spermatogenesis, oogenesis, and tumor progression where it modulates cell proliferation, apoptosis, and metastasis by controlling the stability and translation of key oncogenic and developmental transcripts.
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