SKU: 22271087252

STUP1/CHIP His Tag Protein, Human

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Description

STUP1/CHIP His Tag Protein, HumanProduct Specification Species Human Synonyms CHIP, PP1131, STUB1, E3 ubiquitin protein ligase CHIP, Antigen NY CO 7 Accession Q9UNE7 Amino Acid Sequence Ser23 Tyr303 with His Tag at the N Terminus Expression System E. coli Molecular Weight 33 43kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50mM Tris, 150mM NaCl, pH7. 5, 1mM DTT, 10%Glycerol Stability & Storage Stable

Product Specification


Species Human
Synonyms CHIP, PP1131, STUB1, E3 ubiquitin-protein ligase CHIP, Antigen NY-CO-7
Accession Q9UNE7
Amino Acid Sequence

Ser23-Tyr303 with His Tag at the N-Terminus
Expression System E.coli
Molecular Weight

33-43kDa (Reducing)
Purity ＞95% by SDS-PAGE,> 90% by HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Liquid
Storage Buffer

50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol
Stability & Storage

Stable for 12 months upon stored at -80℃ from the date of receipt. 

And avoid repeated freeze-thaws cycles.
Reference

1. Ballinger, C.A., et al. (1999). Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Molecular and Cellular Biology, 19(6), 4535-4545.
2. Jiang, J., et al. (2001). CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. Journal of Biological Chemistry, 276(46), 42938-42944.

Background

STUB1 (STIP1 Homology and U-Box Containing Protein 1), commonly known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial dual-function protein in cellular proteostasis. It serves as both a co-chaperone and an E3 ubiquitin ligase. As a co-chaperone, it binds to the molecular chaperones Hsp70/Hsc70 and Hsp90 via its N-terminal tetratricopeptide repeat (TPR) domain, assisting in client protein folding and stabilization. Its central role lies in its C-terminal U-box domain, which confers E3 ubiquitin ligase activity. This unique combination allows CHIP to ubiquitinate misfolded or damaged client proteins that are delivered by the chaperones, thereby targeting them for proteasomal degradation. It is a central component of the Protein Quality Control (PQC) system, clearing toxic protein aggregates and maintaining proteome integrity.Dysregulation of CHIP function is linked to various human diseases. Loss-of-function mutations or reduced expression are associated with neurodegenerative disorders (e.g., spinocerebellar ataxia, Alzheimer's, Parkinson's) due to defective clearance of pathogenic proteins like tau and α-synuclein. Conversely, its role in degrading oncogenic clients (e.g., HER2, c-Myc) positions it as a potential tumor suppressor in certain cancers. It also plays key roles in aging, cardiac function, and immune responses, making it a significant therapeutic target.
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Exchange/Return Notes
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SKU: 22271087252

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PrimoCat
Boise, US
★★★★★ 5
Difficult to destroy. Bounce really high.
Style: Squeaker, Size: Small (2 Pack)
Bought as a gift for a friend's small dog who dismantles tennis balls. He loves them. I have many years of experience with the product (in a larger size) for my big dog. He always had one either in his mouth or near him. They are pretty much indestructible.
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Reviewed in the United States on May 13, 2026
M
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Majesty
Cuba, US
★★★★★ 4
High quality, wish it was just a little smaller
Style: Squeaker, Size: Small (2 Pack)
Love these. My dogs would play ball all day if I let them. These are very durable and bouncy. Love that it’s washable. They would chew up the small “tennis” balls to pieces so I love that they can’t destroy these. My only criticism is I wish these were just a little smaller (like the size of the small Kong tennis balls). My dogs can carry it in their tiny mouths but they can’t get their mouth around it enough to chew it to get the squeaker to squeak, which is their favorite thing.
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Reviewed in the United States on January 5, 2026
C
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CA Goose
Chelsea, US
★★★★★ 5
Perfect for little dogs
Style: Ultra, Size: Small (2 Pack)
Perfect size for my 13 pound chihuahua mix. Great bounce and quality feel. Definitely worth it.
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Reviewed in the United States on March 26, 2026
A
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Amazon Customer
Lake Worth, US
★★★★★ 5
The perfect ball for a small to medium dog.
Style: Ultra, Size: Small (2 Pack)
My dog's favorite ball. Perfect size for playing catch and return for a small dog. She loves to chew on the ball. Very durable she has not been able to shred the ball. A great entertainment value. This ball does not squeak.
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Reviewed in the United States on February 27, 2026
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Kristy Kelly
Phoenix, US
★★★★★ 5
High quality, dogs love them
Style: Ultra, Size: Medium (1 Pack)
My dogs are obsessed with these balls! We've had them for months and they're still good as new. High quality!
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Reviewed in the United States on April 5, 2026

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