SKU: 22232577685

ROR2 His Tag Protein, Human

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Description

ROR2 His Tag Protein, HumanProduct Specification Species Human Synonyms ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1 Accession A1L4F5 Amino Acid Sequence Glu34 Gly403, with C terminal 8*His

Product Specification


Species Human
Synonyms ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1
Accession A1L4F5
Amino Acid Sequence Glu34-Gly403, with C-terminal 8*His EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGGGGSHHHHHHHH
Expression System HEK293
Molecular Weight 50-60kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Liu Y. et al. (2007) Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol. 21: 3050-3061.

2、Afzal A R. et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 25: 419-422.

3、van Bokhoven H. et al. (2000) Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 25: 423-426.

Background

Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. ROR2 binds the Wnt family ligand, Wnt-5a, to activate non-canonical Wnt signaling pathways. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cell-polarization, and migration. ROR2 is important for osteogenic and chondrogenic differentiation of mesenchymal stem cells. ROR2 is also involved in neurite outgrowth and synapse development in the brain.
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SKU: 22232577685

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