SKU: 21184259108

KCNQ2 Recombinant Rabbit mAb (S-3465-49)

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Description

KCNQ2 Recombinant Rabbit mAb (S-3465-49)Product Specification Host Rabbit Antigen KCNQ2 Synonyms Potassium voltage gated channel subfamily KQT member 2; KQT like 2; Neuroblastoma specific potassium channel subunit alpha KvLQT2; Voltage gated potassium channel subunit Kv7. 2 Immunogen Synthetic Peptide Location Cell membrane Accession O43526 Clone Number S 3465 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain

Product Specification


Host Rabbit
Antigen KCNQ2
Synonyms Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2
Immunogen Synthetic Peptide
Location Cell membrane
Accession O43526
Clone Number S-3465-49
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The KCNQ2 protein is a voltage-gated potassium channel α-subunit, encoded by the KCNQ2 gene, that plays a critical role in regulating neuronal excitability throughout the central nervous system. Predominantly expressed in the brain, KCNQ2 primarily forms heterotetrameric complexes with KCNQ3 subunits to constitute the M-current (IKM), a slowly activating, non-inactivating potassium current that acts as a crucial brake on repetitive neuronal firing by stabilizing the resting membrane potential and preventing excessive depolarization. Functionally, this current is activated at subthreshold membrane potentials and is essential for controlling action potential threshold, firing frequency, and burst accommodation in neurons. Clinically, mutations in KCNQ2 are associated with a spectrum of epileptic disorders, ranging from benign familial neonatal epilepsy (BFNE) to severe developmental and epileptic encephalopathies (DEE) characterized by refractory seizures, intellectual disability, and neurodevelopmental impairment. The KCNQ2 channel serves as the primary pharmacological target for retigabine (ezogabine), an antiepileptic drug that activates the channel by inducing a conformational shift favoring the open state, thereby enhancing the M-current and reducing neuronal hyperexcitability. Structurally, KCNQ2 contains six transmembrane domains (S1-S6), with the S4 segment functioning as the voltage sensor and the S5-S6 loop forming the channel pore, while intracellular domains mediate subunit assembly, trafficking, and calmodulin-dependent regulation of channel gating kinetics.

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SKU: 21184259108

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