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Description
Rac1/2/3 Recombinant Rabbit mAb (S-2720-10)Product Specification Host Rabbit Antigen Rac1 2 3 Synonyms GX; Small G protein; p21 Rac2; RAC2; Ras like protein TC25; p21 Rac1; RAC1; TC25; p21 Rac3; RAC3 Immunogen Synthetic Peptide Location Cytoplasm Accession P15153P63000P60763 Clone Number S 2720 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, HeLa, HUVEC, SW480, RAW264. 7, NIH 3T3, C2C12, mouse brain, PC 12, C6, rat brain
Product Specification
| Host | Rabbit |
| Antigen | Rac1/2/3 |
| Synonyms | GX; Small G protein; p21-Rac2; RAC2; Ras-like protein TC25; p21-Rac1; RAC1; TC25; p21-Rac3; RAC3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P15153、P63000、P60763 |
| Clone Number | S-2720-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HeLa, HUVEC, SW480, RAW264.7, NIH/3T3, C2C12, mouse brain, PC-12, C6, rat brain |
| Predicted Reactivity | Bv, GP |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu, Ms, Rt |
Background
Rac1/2/3 are highly homologous Rho-family small GTPases that cycle between an inactive GDP-bound and an active GTP-bound state to act as molecular switches relaying extracellular cues to the actin cytoskeleton, thereby orchestrating cell migration, adhesion, membrane ruffling, phagocytosis, and NADPH oxidase–mediated ROS production; while Rac1 is ubiquitously expressed and essential for lamellipodium formation, Rac2 is hematopoietic-specific and predominantly regulates neutrophil ROS generation and chemotaxis, and Rac3, enriched in brain and muscle, fine-tunes neurite outgrowth and synaptic plasticity, yet all three isoforms share overlapping upstream regulators (e.g., Vav, Tiam1, P-Rex1) and downstream effectors (e.g., PAKs, WAVE, formins) and are frequently hyperactivated in cancer, immune disorders, and cardiovascular disease, making them attractive therapeutic targets.
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